Does enhancer RNA play a causative or effectual role in autism?
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Enhancer RNAs (eRNAs) have been implicated in various human diseases, including autism spectrum disorder (ASD). Studies have shown that eRNAs, transcribed from enhancer regions, play a critical regulatory role in gene expression. In the context of ASD, eRNAs have been associated with the regulation of gene expression important for neuronal fate and function, highlighting their involvement in brain disease states. Furthermore, eRNAs have been linked to enhancer activity, enhancer-promoter loops formation, and transcriptional activation, all of which are crucial processes in gene regulation. Therefore, while eRNAs may not directly cause ASD, they likely play an effectual role in modulating gene expression patterns that could contribute to the development or manifestation of autism.
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| Papers (5) | Insight |
|---|---|
| Enhancer RNAs (eRNAs) are implicated in autism spectrum disorder (ASD) through interactions with brain-enriched genes, suggesting a potential effectual role in ASD pathogenesis. | |
3 Citations | Enhancer RNAs play an emerging role in brain diseases, including autism. They regulate transcription and enhancer activity, suggesting a potential effectual role in autism pathogenesis. |
| Enhancer RNAs play a critical role in neuronal gene regulation, predicting enhancer-gene links. While implicated in brain diseases, the paper does not specifically address autism causation by enhancer RNAs. | |
| Not addressed in the paper. | |
13 Citations | Enhancer RNA, specifically MSNP1AS, shows spatiotemporal transcription in the brain at the ASD-associated locus, potentially linking it to autism susceptibility, indicating an effectual role in autism. |
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