Does IGF-I produced by adipose tissue play a role in the angiogenesis?
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Insulin-like growth factor 1 (IGF-1) produced by adipose tissue plays a role in angiogenesis . IGF-1 promotes the formation of vessel-like structures and the recruitment of adipose-derived stem cells (ASCs) in a three-dimensional collagen gel model . It also up-regulates the expression of angiogenesis-related growth factors in endothelial cells (ECs) and ASCs, and activates the PI3-kinase/Akt signaling pathway . The canonical Wnt pathway is involved in ASC-EC-instructed angiogenesis, and Wnt signaling regulates ASC-mediated paracrine signaling during angiogenesis . Adipose tissue angiogenesis is important for tissue repair and is impaired in obesity-associated diseases . A cell-free extract from human fat tissue containing high levels of growth factors, including IGF-1, promotes angiogenesis and attenuates ischemic injury in vivo . Therefore, IGF-1 produced by adipose tissue plays a crucial role in angiogenesis and has therapeutic potential for ischemic disorders.
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| Papers (5) | Insight |
|---|---|
| The paper does not specifically mention the role of IGF-I produced by adipose tissue in angiogenesis. | |
| The paper mentions that IGF-1 signaling plays a critical role in mediating adipose tissue angiogenesis and hyperplastic adipose tissue expansion. Therefore, IGF-I produced by adipose tissue does play a role in angiogenesis. | |
52 Citations | The paper does not specifically mention the role of IGF-I produced by adipose tissue in angiogenesis. The paper focuses on the role of canonical Wnt signaling in angiogenesis using a 3D model containing adipose tissue stem cells and endothelial cells. |
| Yes, the paper states that insulin-like growth factor 1 (IGF-1) improves the angiogenic activity of adipose tissue-derived microvascular fragments (ad-MVFs). | |
| Yes, the paper states that IGF-1 promotes angiogenesis in a co-culture system of endothelial cells (ECs) and adipose-derived stem cells (ASCs). |
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