M
Matthias W. Laschke
Researcher at Saarland University
Publications - 291
Citations - 8750
Matthias W. Laschke is an academic researcher from Saarland University. The author has contributed to research in topics: Medicine & Angiogenesis. The author has an hindex of 44, co-authored 250 publications receiving 7127 citations. Previous affiliations of Matthias W. Laschke include AO Foundation & Malmö University.
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Journal ArticleDOI
Angiogenesis in tissue engineering: breathing life into constructed tissue substitutes.
Matthias W. Laschke,Yves Harder,Yves Harder,Michaela Amon,Ivan Martin,Jian Farhadi,Andrej Ring,Nestor Torio-Padron,René Schramm,Martin Rücker,Dominic Junker,Jörg M. Häufel,Carlos Carvalho,Michael Heberer,Günter Germann,Brigitte Vollmar,Michael D. Menger +16 more
TL;DR: Future directions of research should focus on the creation of microvascular networks within 3D tissue constructs in vitro before implantation or by co-stimulation of angiogenesis and parenchymal cell proliferation to engineer the vascularized tissue substitute in situ.
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Overcoming Intrinsic Multidrug Resistance in Melanoma by Blocking the Mitochondrial Respiratory Chain of Slow-Cycling JARID1Bhigh Cells
Alexander Roesch,Adina Vultur,Ivan Bogeski,Huan Wang,Katharina M. Zimmermann,David W. Speicher,Christina Körbel,Matthias W. Laschke,Phyllis A. Gimotty,Stephan E. Philipp,Elmar Krause,Sylvie Pätzold,Jessie Villanueva,Clemens Krepler,Mizuho Fukunaga-Kalabis,Markus Hoth,Boris C. Bastian,Thomas Vogt,Meenhard Herlyn +18 more
TL;DR: These findings support a two-tiered approach combining anticancer agents that eliminate rapidly proliferating melanoma cells with inhibitors of the drug-resistant slow-cycling subpopulation, and support an intrinsic multidrug resistance based on the survival of a tumor cell subpopulation.
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Life is 3D: Boosting Spheroid Function for Tissue Engineering
TL;DR: In vitro preconditioning under different culture conditions and incorporation of biomaterials improve the function of spheroids and their directed fusion into macrotissues of desired shapes, and may markedly contribute to a broad implementation of spheroid-based tissue engineering in future regenerative medicine.
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Angiogenic and inflammatory response to biodegradable scaffolds in dorsal skinfold chambers of mice.
Martin Rücker,Matthias W. Laschke,Dominik Junker,Carlos Carvalho,Alexander Schramm,Rolf Mülhaupt,Nils-Claudius Gellrich,Michael D. Menger +7 more
TL;DR: PLGA scaffolds show a better biocompatibility than hydrogel scaffolds and promote vascular ingrowth, guaranteeing adequate engraftment within the host tissue.
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Prevascularization in tissue engineering: Current concepts and future directions.
TL;DR: An overview of current strategies for the generation of preformed microvascular networks within tissue constructs and their adaptation to individual therapeutic interventions will markedly contribute to a broad implementation of tissue engineering applications into clinical practice.