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Does inflammation alter DNA methylation? 

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CpG site
KEGG
Carcinogenesis
Mendelian randomization
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Yes, inflammation significantly alters DNA methylation, a process that plays a crucial role in various diseases, including cancer and intracerebral hemorrhage (ICH). Research using a murine model of inflammation-induced tumorigenesis demonstrated that inflammation promotes the recruitment of epigenetic proteins to chromatin, initiating methylation and gene silencing in tumors, highlighting a novel mechanism of epigenetic alterations in inflammation-driven cancer. Similarly, studies on ICH identified 22 differentially expressed methylation-regulated and inflammation-related genes (DE-MIRGs), suggesting that inflammation and DNA methylation are interconnected in the pathology of ICH. A multi-ethnic Epigenome Wide Association study found 1,511 differentially methylated loci associated with chronic low-grade inflammation, as measured by C-Reactive protein (CRP), indicating that inflammation can lead to widespread changes in DNA methylation across the genome. In lung cancer, inflammation-related DNA methylation alterations in blood were linked to lung cancer risk and survival, providing insight into the role of inflammation in lung cancer etiology. Research in rheumatoid arthritis (RA) showed that DNA methylation changes in monocytes are determined by extracellular signals, including inflammation-associated cytokines, which correlate with RA disease activity. A study on inflammation-induced colon tumorigenesis found that treating mice with a DNA methyltransferase inhibitor reduced tumorigenesis and altered inflammation-specific DNA hypermethylation. Lastly, in the context of preterm birth and bronchopulmonary dysplasia (BPD), maternal inflammation and neonatal hyperoxia were shown to contribute to epigenetic changes, including alterations in DNA and histone methylation, affecting gene expression. These findings across various studies and diseases underscore the significant impact of inflammation on DNA methylation, suggesting that inflammation can induce epigenetic changes that contribute to disease development and progression.

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Papers (6)Insight
Open access•Posted Content•DOI
Identification and analysis of DNA methylation inflammation related key genes in intracerebral hemorrhage
14 Feb 2023
Intracerebral hemorrhage study suggests inflammation influences DNA methylation. Identified key genes SELP and S100A4 linked to inflammation and methylation changes, indicating a potential alteration relationship.
Open access•Posted Content•DOI
Methylation-derived Inflammatory Measures and Lung Cancer Risk and Survival
Naisi Zhao, Mengyuan Ruan, Devin C. Koestler, Jiayun Lu, Karl T. Kelsey, Elizabeth A. Platz, Dominique S. Michaud, Dominique S. Michaud 
26 May 2021-medRxiv
1 Citations
Inflammation-related DNA methylation changes were observed in lung cancer risk and survival, indicating that inflammation can indeed alter DNA methylation.
Open access•Journal Article•DOI
DNA methylation signature of chronic low-grade inflammation and its role in cardio-respiratory diseases
Matthias Wielscher
03 May 2022-Nature Communications
12 Citations
Yes, chronic low-grade inflammation alters DNA methylation, with CpG sites associated with C-Reactive Protein levels, influenced by factors like obesity and smoking, impacting cardio-respiratory diseases.
Posted Content•DOI
Table S2 from Mismatch Repair Proteins Initiate Epigenetic Alterations during Inflammation-Driven Tumorigenesis
31 Mar 2023
Yes, inflammation-driven tumorigenesis can lead to epigenetic alterations, including DNA methylation changes initiated by mismatch repair proteins, as shown in the study's MBD-seq data.
Posted Content•DOI
Table S2 from Mismatch Repair Proteins Initiate Epigenetic Alterations during Inflammation-Driven Tumorigenesis
31 Mar 2023
Yes, inflammation-driven tumorigenesis can lead to significant differentially methylated regions, as shown in the MBD-seq data from the study.
Open access•Journal Article•DOI
Identification and Analysis of DNA Methylation Inflammation-Related Key Genes in Intracerebral Hemorrhage.
Sanpeng Xu, Qiong Wu, Zhe Tang, Ping Li 
24 Jun 2023-Biochemical Genetics
Intracerebral hemorrhage study suggests inflammation-related genes influence DNA methylation. Inflammation can impact DNA methylation patterns, potentially affecting gene expression and disease development.

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