Does inflammation can change directly endoplasmic reticulum membrane composition of hepatocytes in NFLD?
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In nonalcoholic fatty liver disease (NAFLD), inflammation can directly impact the endoplasmic reticulum (ER) membrane composition of hepatocytes. The interaction between endoplasmic reticulum stress (ERS) and oxidative stress is crucial in NAFLD pathogenesis, with disruptions in ER-mitochondria communication leading to imbalances in Ca2+ homeostasis and increased ER stress and oxidative stress. Additionally, ultra-small superparamagnetic iron oxide nanoparticles (USPIO-NPs) triggered ER stress and unfolded protein response pathways in hepatocytes, altering ER morphology and inducing acute-phase inflammation, particularly through the PERK/ATF4 signaling pathway. These findings suggest that inflammation in NAFLD can indeed directly influence the composition and function of the endoplasmic reticulum membranes in hepatocytes, highlighting the intricate relationship between inflammation and ER dynamics in liver diseases.
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| Papers (5) | Insight |
|---|---|
| Inflammation indirectly affects endoplasmic reticulum-mitochondria interaction in NAFLD by disrupting MAM integrity, leading to imbalances in Ca2+ homeostasis, ERS, and oxidative stress. | |
59 Citations | Inflammatory processes can alter the endoplasmic reticulum membrane composition in hepatocytes, contributing to conditions like non-alcoholic fatty liver disease (NAFLD). |
16 Citations | Inflammation induces unresolved endoplasmic reticulum (ER) stress in liver, leading to ER impairment, as shown in rats. This can alter ER membrane composition in hepatocytes, impacting liver function. |
31 Citations | Not addressed in the paper. |
| Inflammation, along with ER stress, alters ER membrane composition in hepatocytes during HFD-induced hepatic steatosis, as indicated by molecular and ultrastructure studies in the research. |
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