What is the effect of low protein diet on kidneys?4 answersA low-protein diet plays a crucial role in managing chronic kidney disease (CKD) by slowing down kidney function deterioration and controlling metabolic variables like serum phosphate and urea. Studies have shown that implementing a low-protein diet can lead to a decrease in protein intake, body weight, BMI, fat mass, serum phosphate, and urea levels, while increasing free-fat mass percentage. Additionally, a very low-protein diet supplemented with essential amino acids has been found to effectively delay the progression of CKD and postpone the need for dialysis treatment. Furthermore, evidence suggests that a plant-dominant low-protein diet may offer benefits in managing CKD by alleviating uremic burden, controlling metabolic complications, and potentially reducing cardiovascular risk. Overall, a well-monitored low-protein diet can help in mitigating the progression of CKD and improving metabolic outcomes in affected individuals.
Are low-protein diets conducive to longevity?5 answersLow-protein diets have shown promising results in promoting longevity and metabolic health. Studies indicate that reducing protein intake, particularly branched-chain amino acids (BCAAs), can lead to improved lifespan, metabolic function, and reduced mortality in humans and rodents. Additionally, low-protein diets have been associated with increased lifespan, improved cardiometabolic health, and decreased adiposity in animal models. Furthermore, protein restriction has been linked to delaying age-related diseases and improving overall health. In the context of chronic kidney disease (CKD), low-protein diets have been effective in managing advanced CKD, optimizing blood pressure control, and postponing kidney replacement therapy, especially in elderly patients. Therefore, low-protein diets, particularly those focusing on BCAA restriction, show promise in promoting healthy longevity and metabolic well-being.
How much protein should a person eat per day?5 answersA person should consume approximately 90-100 g of protein per day, primarily from animal sources, despite the increasing need for vegetable protein. Animal feed with insufficient protein leads to higher fodder consumption, increasing the need for plant protein. The EFSA Panel on Dietetic Products recommends an average protein requirement of 0.66 g/kg body weight per day for healthy adults, with a Population Reference Intake (PRI) of 0.83 g/kg body weight per day. Meeting the daily protein recommendation of ≥1.0 g/kg/day is associated with decreased odds of functional disability in older Americans. The indicator amino acid oxidation (IAAO) method suggests that minimum protein requirements have been underestimated by 30-50%, and a variety of high-quality proteins at a range of 1.5-2.2 g/(kg·day) is suggested.
Whats the effect of low protein diet on tumor growth?5 answersA low protein diet has been shown to have a significant effect on tumor growth. Severe and continuous protein restriction was found to reduce tumor growth in a Drosophila melanogaster intestinal tumor model. Additionally, a diet that alternated short periods of severe protein restriction with periods of complete feeding was able to reduce tumor mass and restore gut functionality. This cyclic nutritional regime also normalized the lifespan of oncogene-expressing flies to the levels observed in healthy control flies. Furthermore, this diet was found to reduce chemotherapy-induced stem cell activity associated with tumor recurrence. The data suggests that recurrent severe protein depletion effectively mimics the health benefits of continuous protein restriction without undesired nutritional shortcomings.
Do changes in kidney function differ between healthy adults consuming higher- compared with lower- or normal-protein diets?5 answersChanges in kidney function differ between healthy adults consuming higher- compared with lower- or normal-protein diets. Evidence suggests that low dietary protein intake (DPI) leads to attenuation of kidney function decline in chronic kidney disease (CKD) patients, while a higher DPI is associated with higher mortality in participants with impaired kidney function. On the other hand, a low DPI is associated with higher mortality in individuals with normal kidney function. Additionally, chronic low protein intake decreases glomerular filtration rates and kidney mass, while increasing kidney immune infiltration and structural injury. Animal protein has been associated with an increased risk of end-stage kidney disease (ESKD) compared to protein from plant sources. Therefore, the impact of protein intake on kidney function differs depending on the individual's kidney function status and the source of protein consumed.
What are the effects of high protein intake on health?5 answersHigh protein intake has been found to have several effects on health. Consuming more protein than the recommended dietary allowance can lead to reductions in body weight and fat mass while preserving fat-free mass. It can also increase satiety signaling and reduce food intake through the release of anorexigenic hormones and the stimulation of metabolic pathways. High protein diets have been associated with greater satiety and weight loss compared to high carbohydrate diets. There is no evidence of adverse effects on bone density or renal function in healthy individuals. However, long-term consumption of high amounts of protein may be linked to metabolic and clinical problems in some cases. Further research is needed to fully understand the long-term effects of high protein intake on health.