Explain why the same concentrations of internal standard is added to all solutions in gas chromatography?
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In gas chromatography, the same concentrations of internal standard are added to all solutions to compensate for variations in sample size, detector sensitivity, and procedural errors. The internal standard method aims to improve accuracy by correcting for detector response variations and sample mass differences. Utilizing internal standards helps in quantifying semi-volatile organic compounds precisely, especially when volume errors are unpredictable. The addition of internal standards promptly upon preparation is crucial to avoid introducing uncertainty into quantitation. The method of using ethanol as an internal standard in gas chromatography has been shown to provide accurate results with minimal bias. Overall, the consistent addition of internal standards ensures reliable and accurate quantification of compounds in gas chromatography analyses.
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| Papers (5) | Insight |
|---|---|
| Internal Standard (ISTD) in gas chromatography compensates for sample size variations by adding the same concentrations to all solutions, aiding in accurate quantification despite non-linear detector responses. | |
19 Citations | Adding the same concentration of internal standard to all solutions in gas chromatography ensures accurate correction for procedural errors, enhancing the precision and reliability of quantitative analysis results. |
Open access•Posted Content | In gas chromatography, adding the same concentrations of internal standard, like ethanol, ensures consistent relative response factors for volatile compounds, enabling accurate quantification across different samples. |
| In gas chromatography, adding the same concentrations of internal standards to all solutions ensures accurate quantification of semi-volatile organic compounds by minimizing variability and errors in measurements. | |
3 Citations | Adding the same concentrations of internal standard in gas chromatography ensures compensation for variations in injected mass, especially when using relative concentration/calibration arithmetic to address nonlinearity in calibrations. |
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