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How are FOXO3 and NAMPT signaling related in adipocytes?

Glucocorticoid receptor

Transcription factor

Protein kinase A

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FOXO3 and NAMPT signaling are interconnected in adipocytes. FOXO3a, a transcription factor, plays a crucial role in regulating autophagy, lipid accumulation, and inflammation in adipocytes . On the other hand, NAMPT, a cytokine secreted by adipose tissue, is involved in immunoreactions, inflammation, and lipid metabolism . FOXO3a interacts with the ATM-Chk2-p53 complex to induce DNA damage-induced apoptosis, highlighting its role in cellular responses to stress . Additionally, FOXO3 transcription is enhanced by glucocorticoid receptor (GR) activation and metabolic stress, with AMPK further amplifying this effect . This intricate network suggests that FOXO3 and NAMPT signaling pathways are intertwined in regulating various aspects of adipocyte function, including autophagy, lipid metabolism, inflammation, and stress responses.

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Open access•Journal Article•DOI FOXO3 is a glucocorticoid receptor target and regulates LKB1 and its own expression based on cellular AMP levels via a positive autoregulatory loop Nicolas Lützner, Hubert Kalbacher, Anja Krones-Herzig, Frank Rösl - Show less +3 more 27 Jul 2012-PLOS ONE 78 Citations	Not addressed in the paper.
Journal Article•DOI Nampt affects mitochondrial function in aged oocytes by mediating the downstream effector FoxO3a. Qingrui Zhuan, Jun Li, Xingzhu Du, Luyao Zhang, Lin Meng, Keren Cheng, Shi-En Zhu, Yunpeng Hou, Xiangwei Fu - Show less +8 more 28 Jul 2021-Journal of Cellular Physiology 6 Citations	FOXO3 and NAMPT signaling are related in aged oocytes, where NAMPT affects mitochondrial function by mediating FOXO3a, leading to compromised oocyte quality and developmental competence.
Journal Article•DOI FOXO3a regulates lipid accumulation and adipocyte inflammation in adipocytes through autophagy : Role of FOXO3a in obesity. Xiaoyan Zhang, Qiang Liu, Xuane Zhang, Kai Guo, Xuelian Zhang, Zunhai Zhou - Show less +5 more 23 Apr 2021-Inflammation Research 9 Citations	FOXO3a regulates lipid accumulation and inflammation in adipocytes through autophagy. The paper does not address the relationship between FOXO3 and NAMPT signaling in adipocytes.
Journal Article•DOI Transcriptional Regulation of NAMPT Gene by Glycogen Synthase Kinase 3β in Goat Adipocytes. Linjie Wang, Xueying Li, Zhe Chao, Tao Zhong, Jiazhong Guo, Yan Wang, Li Li, Hongping Zhang - Show less +7 more 05 Mar 2019-DNA and Cell Biology 3 Citations	Not addressed in the paper.

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