How are FOXO3 and NAMPT signaling related to each other?
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FOXO3 and NAMPT signaling are interconnected in various biological processes. FOXO3, a transcription factor, plays a role in cell survival, stress response, and longevity . NAMPT, on the other hand, is involved in mitochondrial function and tumorigenicity regulation . In aged oocytes, elevated FoxO3a expression is associated with mitochondrial dysfunction, while Nampt expression is increased, impacting mitochondrial function negatively . Additionally, in tumor-associated neutrophils, NAMPT is crucial for their tumorigenic conversion, promoting tumor growth and angiogenesis . The relationship between FOXO3 and NAMPT highlights their significance in cellular processes, aging, and cancer progression, suggesting potential therapeutic targets for age-related diseases and cancer treatment.
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| Papers (5) | Insight |
|---|---|
| FOXO3 regulates aging and aging-related diseases. While NAMPT is not directly mentioned, FOXO3's involvement in signaling pathways suggests potential interactions with NAMPT in aging processes. | |
6 Citations | FOXO3 and NAMPT signaling are linked in aged oocytes, where NAMPT affects mitochondrial function by mediating FOXO3a, leading to compromised oocyte quality and developmental competence. |
48 Citations | FOXO3 and NAMPT signaling are not directly addressed in the paper. |
14 Citations | FOXO3 is a latent tumor suppressor in FOXO3-positive gastric cancer cells. NAMPT signaling's relationship with FOXO3 in this context is not addressed in the paper. |
11 Mar 2023 | Not addressed in the paper. |
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