How are magnetic nanoparticles used for hyperthermia?
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Magnetic nanoparticles (NPs) are commonly used for hyperthermia, a form of thermotherapy used to kill tumor cells with heat. These NPs, usually made of magnetic iron oxide such as magnetite or maghemite, can be "switched on" by an external magnetic field, causing them to heat up near tumor cells. Under an applied AC magnetic field, the magnetic spin of the NPs rapidly switches direction, converting magnetic energy into thermal energy. This localized heating, with temperatures of 41-46 °C, inhibits tumor cell growth, kills them, or induces tumor cell apoptosis. Magnetic NPs have been used in tumor thermotherapy since 1996 and have shown synergistic effects when combined with other therapies such as surgery, radiotherapy, and chemotherapy . The size of the NPs is crucial for their heating efficiency, and various parameters such as the surrounding medium, concentration, and field amplitude and frequency can be adjusted to optimize the heating efficiency for different NP sizes . Additionally, magnetic NPs can be coated with proteins such as Bovine Serum Albumin (BSA) to enhance their biocompatibility and specific absorption rate, making them suitable for future hyperthermia applications . The heat transfer from magnetic NPs to the surroundings occurs through a resonance mechanism, allowing for directional control of heat flow and potential activation or release of (bio)molecules anchored to the NPs .
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| The paper discusses the use of Lanthanum Strontium Manganese Oxide (LSMO) nanoparticles coated with Bovine Serum Albumin (BSA) for magnetic hyperthermia applications. The LSMO nanoparticles generate heat when subjected to a radiofrequency magnetic field, making them suitable for hyperthermia treatment. | |
1 Citations | Magnetic nanoparticles (MNPs) are subjected to an alternating magnetic field to generate heat for hyperthermia treatment of cancer cells. |
25 Mar 2023 | Magnetic oxide nanoparticles are used in hyperthermia by heating up near tumor cells when exposed to an applied AC magnetic field, killing or inhibiting the growth of the cells. |
| Magnetic oxide nanoparticles are used in hyperthermia by heating up near tumor cells when exposed to an applied AC magnetic field, killing or inhibiting the growth of the cells. |
Related Questions
What are the potential benefits and risks associated with hyperthermia treatment for cancer patients?4 answersHyperthermia treatment in cancer therapy offers benefits such as improved tumor response, pain relief, and sensitization to radiotherapy and chemotherapy, potentially enhancing treatment outcomes. It acts as a potent radiosensitizer, chemosensitizer, and immunomodulator, particularly effective in recurrent breast cancers, locally advanced cervix cancer, and head and neck cancers. However, evidence regarding the improvement of survival or quality of life is lacking for both whole-body hyperthermia and electro hyperthermia. Challenges in establishing a clear thermal dose effect relationship exist due to inconsistent reporting of hyperthermia treatment characteristics in clinical studies. Despite the benefits, hyperthermia may pose risks such as acute toxicities during treatment, emphasizing the need for careful monitoring and management.
What is the recent evelopment onmagnetic hyperthermia?5 answersRecent developments in magnetic hyperthermia include the expansion of the concept of hyperthermia to include temperature-based treatment and magnetically controlled medication delivery. Magnetic hyperthermia has shown potential as a standalone intervention or adjunct to radiotherapy and chemotherapy in the treatment of cancer. Efforts have been made to improve the heating generation efficiency of magnetic nanoparticles (MNPs) for better treatment effectiveness. Superparamagnetic iron oxide nanoparticles (SPIONs) have been studied for their ability to induce hyperthermia and their interactions with magnetic fields. Strategies to efficiently deliver SPIONs to the target site have also been explored. In addition, research has focused on understanding the molecular interactions between iron oxide nanoparticles and the biological environment. Future considerations for the clinical adoption of magnetic hyperthermia include addressing challenges such as heat dissipation potency, dose concentration, and real-time temperature monitoring.
The usage of magnetic nanoparticles?5 answersMagnetic nanoparticles have a wide range of applications in various fields including biomedical, environmental science, and engineering. They possess unique properties such as high surface area, size-dependent superparamagnetic properties, and easy surface modification, making them suitable for diverse uses. In the biomedical field, magnetic nanoparticles are utilized in drug delivery, magnetic hyperthermia, magnetic resonance imaging, magnetic particle imaging, biosensors, and tissue engineering. They are also used in magnetorheological fluids, wastewater treatment, and nanomedicine for health sector applications. Magnetic nanoparticles play a crucial role in catalysis, mineralogy, data storage, and environmental science for pollutant concentration. Additionally, they are employed in magnetic separation, target drug delivery, magnetic resonance imaging contrast enhancement, and magnetic hyperthermia for tumor treatment. In the field of environmental science and engineering, magnetic nanoparticles are used for the purification of whey, removal of toxic metals and pollutants from water, and photocatalytic degradation of dyes and pollutants.
What is the effect of hylaronic acid grafted chitosan functionlazied cobalt ferrite on hyperthermia medicated drug delivery system?5 answersHyaluronic acid grafted chitosan functionalized cobalt ferrite nanoparticles have been studied for their effect on hyperthermia-mediated drug delivery systems. The combination of chitosan and hyaluronic acid enhances the specific absorption rate (SAR) properties of cobalt ferrite nanoparticles, making them effective heat nanomediators for hyperthermia. The chitosan-coated cobalt ferrite nanoparticles show a maximum SAR of 386 W/g, compared to 270 W/g for bare nanoparticles. The chitosan-coated nanoparticles also provide biocompatibility and stability to the samples, making them suitable for biomedical applications. The magnetic heating efficiency of chitosan-coated cobalt ferrite nanoparticles has been investigated, and they have shown high specific loss power, indicating their potential as magnetic mediators for hyperthermia applications. The chitosan-coated cobalt ferrite nanoparticles have also been found to have controlled drug release properties and are non-cytotoxic. Overall, the combination of hyaluronic acid grafted chitosan and cobalt ferrite nanoparticles shows promise for hyperthermia-mediated drug delivery systems.
How does temperature affect breast cancer cells in hyperthermia and nanoparticle-mediated photothermal therapy?5 answersTemperature plays a crucial role in hyperthermia and nanoparticle-mediated photothermal therapy (PTT) for breast cancer cells. Hyperthermia involves heating cancer cells to a specific temperature to induce cell death. Overexpressed heat shock proteins (HSPs) in cancer cells can limit the benefits of PTT. Inhibition of stress granule (SG) formation, which is triggered by HSPs, can sensitize tumor cells to PTT. Nanoparticles, such as gold nanostructures, are commonly used in PTT due to their high photothermal conversion efficiency. These nanoparticles can generate heat when exposed to near infrared (NIR) light, leading to cancer cell death. The use of nanomaterials in PTT also allows for targeted delivery of the therapy to breast cancer cells, increasing its effectiveness. Additionally, combining PTT with other treatments, such as chemotherapy, can further enhance the therapeutic effect on breast cancer cells. Overall, temperature plays a critical role in hyperthermia and nanoparticle-mediated PTT, influencing the effectiveness of the therapy on breast cancer cells.
What is hyperthermia in birds?4 answersHyperthermia in birds refers to the elevation of body temperature above normal levels. It has been suggested that hyperthermia contributes to a reduction in total evaporative water loss in birds, especially those living in deserts. Birds in hot environments use hyperthermia as a mechanism to offset the costs of thermoregulation and excessive water loss. In captivity, birds allow their body temperature to increase, entering a state of hyperthermia, to dissipate metabolically generated heat. Hyperthermia in birds is also observed during handling in stressful situations. However, it is unclear whether stress-induced hyperthermia is differently regulated in birds or if it is due to size differences. Overall, hyperthermia in birds is a physiological response that helps them cope with high ambient temperatures and conserve energy.