•How can humans get exposed to nanoparticles? And Why is understanding nanoparticle toxicity crucial for public health and safety?
Best insight from top research papers
Humans can get exposed to nanoparticles through the increasing presence of nanomaterials in various aspects of daily life, leading to inevitable exposure due to their release into the environment . Nanomaterials, including metal-based nanoparticles, possess unique physicochemical properties that offer benefits but also pose unexpected toxic threats to human health . Understanding nanoparticle toxicity is crucial for public health and safety as it allows for the assessment of potential risks associated with exposure to nanomaterials, especially engineered nanomaterials (ENMs) that can penetrate the blood-brain barrier . This understanding is essential for developing safer applications of nanomaterials, minimizing risks, and promoting the safe handling of nanomaterials in various industries, ultimately ensuring human and environmental safety .
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| Papers (5) | Insight |
|---|---|
28 Citations | Humans can get exposed to nanoparticles through inhalation, ingestion, or skin contact. Understanding nanoparticle toxicity is crucial for public health to mitigate adverse effects on the environment and human health. |
8 Citations | Humans can be exposed to metal-based nanoparticles through various sources. Understanding nanoparticle toxicity is crucial for public health to mitigate potential harm and ensure safe application in biomedical settings. |
| Humans can be exposed to nanoparticles through various sources like biomedicine, engineering, and cosmetics. Understanding nanoparticle toxicity is crucial for public health to mitigate risks associated with their widespread use. | |
3 Citations | Humans can be exposed to nanoparticles through various sources. Understanding nanoparticle toxicity is crucial for public health due to potential risks associated with their permeability and diverse applications. |
| Humans can be exposed to nanoparticles through various sources. Understanding nanoparticle toxicity is crucial for public health and safety due to the widespread use of nanomaterials in daily life. |
Related Questions
What is the potential toxicity and safety of nanoparticles?5 answersNanoparticles exhibit both potential toxicity and safety concerns. Their unique properties make them valuable in various sectors like healthcare, cosmetics, and electronics. However, nanoparticles can lead to oxidative stress, inflammation, and organ damage due to their increased surface area and interactions with biomolecules. Studies highlight that constant exposure to nanoparticles like gold, silver, and titanium dioxide can result in respiratory disorders, behavioral changes, neurological issues, and even cancer. On the other hand, nanoparticles have shown promise in drug delivery systems for ocular diseases, offering biocompatibility and few side effects. To ensure safety, regulations must be updated, and toxicity assessments should be thorough to mitigate risks associated with nanoparticle exposure.
What studies look into health risks in nanomaterials?4 answersStudies on health risks in nanomaterials have been conducted to understand the potential adverse effects of exposure. Research has shown that nanomaterials can have a higher reactivity and toxicity due to their small size and increased surface area. The impact of nanomaterials on human health is complex and not fully understood, but in vitro and in vivo studies using animal models have provided insights into the adverse effects of nanomaterial exposure. These studies have shown that the route of exposure, such as oral, dermal, intravenous, or inhalation, can influence the adverse effects on human health. Additionally, the type of nanomaterial, as well as its size, shape, functionalization, and defects, can significantly alter the toxicity. Occupational health hazards have also been identified for workers involved in the synthesis and packaging of nanomaterial-based products. Overall, research on nanomaterials has focused on understanding their toxicity and potential health risks in order to inform risk assessment strategies.
How do Nanoparticles cause toxicity in earthworms?5 answersNanoparticles cause toxicity in earthworms through various mechanisms. Exposure to metal oxide nanoparticles, such as ZnO and CuO, can lead to the accumulation of organic pollutants, such as pesticides, in earthworms, resulting in higher tissue concentrations. Nanoparticles can also induce oxidative stress in earthworms, leading to the production of reactive oxygen species (ROS) and damage to cell membranes. This oxidative stress can affect biomarkers such as superoxide dismutase (SOD) and malondialdehyde (MDA). Additionally, nanoparticles can impact earthworm reproduction and survival, as well as influence the bioavailability and toxicity of metals in the soil. The specific mechanisms by which nanoparticles cause toxicity in earthworms are still being investigated, but these studies highlight the potential risks associated with nanoparticle exposure in soil ecosystems.
How do nanoparticles affect the environment?4 answersNanoparticles have been found to have various effects on the environment. They can accumulate in soil, sediments, water, air, and biota, leading to potential risks for both the environment and human health. In particular, the presence of metal and metal oxide nanoparticles in the environment can adversely affect microbial diversity and activity in the soil, which is crucial for soil fertility and biogeochemical cycles. Prolonged exposure to nanoparticles can also have harmful effects on human health and wildlife, raising concerns about their safety. Additionally, nanomaterials released into the natural environment can impact microbial communities, with different environmental conditions and characteristics of the nanomaterials influencing the structure and function of these communities. While nanoparticles have been used in environmental remediation, it is important to study and assess their environmental effects and interactions with living organisms, as well as their accumulation in ecosystems.
Why are nanoparticles toxic?4 answersNanoparticles can be toxic due to their increased bioactivity compared to their bulk counterparts. They can induce oxidative stress, genotoxicity, and biochemical alterations in cells. Nanomaterials such as carbon nanotubes, quantum dots, and metallic and nonmetallic nanoparticles have been reported to be toxic to cells in vivo and in vitro. The toxic effects of nanoparticles can be neutralized using strategies such as biocompatible materials, surface modification, and immunosuppressant nanoparticles. Nanoparticles can also cause toxic effects in various metabolic steps in organisms, including structural proteins, genetic structure, organelles, cells, tissues, organs, and metabolic systems. The toxicity of nanoparticles is a concern in various fields, including medicine, pharmaceuticals, molecular studies, and agriculture. The interaction of nanoparticles with the plant genome can result in genotoxic effects, such as structural chromosomal aberrations and disruption of the cell cycle and DNA repair system.
What are the harmful effects of nanoparticles?5 answersNanoparticles have been found to have harmful effects on human health and the environment. Prolonged exposure to nanoparticles can lead to serious concerns for human health and wildlife, as they can interact with various mechanisms and cause adverse effects. Studies have shown that nanoparticles can penetrate biological systems, including the blood-brain barrier, and leak into internal organs. The toxicity of nanoparticles is concentration-dependent and time-dependent, and can lead to damaged DNA, generation of reactive oxygen species (ROS), and cytotoxic effects. Nanoparticles can also have toxicological and behavioral effects on aquatic creatures, plants, and human health, due to their small size, large surface area, and ability to generate ROS. It is important to understand the potential harmful effects of nanoparticles and take preventive actions to control human exposure to toxic nanoparticles.