How can i demonstrate the relationship between hydrophobicity and hemostasis？?
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Hydrophobicity and hemostasis are related through the interaction between hydrophobic surfaces and blood coagulation factors. The crystal structures of blood coagulation cofactors Va and VIIIa suggest that their membrane-binding C2 domains bind anionic phospholipids through hydrophobic residues . Additionally, the coagulation behavior of coal and silica samples has been studied, and it has been found that the classical DLVO theory is not applicable to strongly hydrophobic solids. To extend the theory, hydrophobic interaction energies have been considered, which can be described in terms of the nondispersion interaction between water and solid . Furthermore, the number of bounces of water droplets on superhydrophobic surfaces has been found to be related to the static water contact angle, droplet size, droplet density, droplet surface tension, surface microstructure, and surface free energy of interaction with water . Therefore, the hydrophobicity of surfaces can influence the behavior of blood coagulation factors and hemostasis.
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109 Citations | The paper discusses the coagulation behavior of hydrophobic solids and proposes a method to extend the DLVO theory to describe the stability of very hydrophobic particle suspensions. |
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