How Changes In The Shape Of Brain Neurons Lead To Middle-Age Obesity?
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Changes in the shape of brain neurons can lead to middle-age obesity. One study found that ectopic expression of HB-EGF in neuroepithelial progenitors resulted in the development of spontaneous obesity in male mice, accompanied by hyperglycemia and insulin resistance . Another study showed that chronic activation of hypothalamic GABAergic neurons or non-AgRP GABA+ neurons in the arcuate nucleus led to obesity, while chronic inhibition of these neurons reduced weight gain . Additionally, obesity has been associated with structural brain changes and rates of brain atrophy, particularly in individuals developing cognitive impairment and dementia . Furthermore, obesity has been linked to neuroinflammation and mitochondrial dysfunction, which can contribute to cognitive decline . These findings suggest that alterations in brain neuron activity, neuroinflammation, and mitochondrial dysfunction may play a role in the development of middle-age obesity.
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| The provided paper does not discuss changes in the shape of brain neurons leading to middle-age obesity. | |
| The provided paper does not discuss changes in the shape of brain neurons leading to middle-age obesity. | |
69 Citations | The provided paper does not discuss how changes in the shape of brain neurons lead to middle-age obesity. |
2 Citations | The provided paper does not discuss changes in the shape of brain neurons leading to middle-age obesity. |
27 Jul 2020 45 Citations | The provided paper does not specifically discuss how changes in the shape of brain neurons lead to middle-age obesity. The paper focuses on the role of arcuate GABA+ neurons in obesity development. |
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