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How do calcium levels affect the differentiation of myofibroblasts in various tissues? 

Calcineurin
Endoplasmic reticulum
Myofibroblast
Glaucoma
Optic nerve
Best insight from top research papers

Calcium levels play a crucial role in the differentiation of myofibroblasts in different tissues. In pulmonary fibrosis, calcium impacts myofibroblast migration and death regulation. Glaucoma research highlights abnormal calcium signaling in LC fibroblast cells, affecting physiological processes and contributing to fibrosis. Moyamoya disease elevates angiogenic factors due to calcium signaling, promoting fibroblast proliferation and collagen production. Gypenosides ameliorate liver fibrosis by inhibiting TGF-β signaling, preventing the differentiation of hepatic progenitor cells into myofibroblasts. In skeletal muscle differentiation, calcineurin and PKCβ regulate myogenesis through calcium-dependent pathways, affecting chromatin remodeling and gene expression. Overall, calcium levels influence myofibroblast differentiation by modulating migration, proliferation, and gene expression in various tissues.

Answers from top 5 papers

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Papers (5)Insight
Open access•Journal Article•DOI
Opposing calcium-dependent signalling pathways control skeletal muscle differentiation by regulating a chromatin remodelling enzyme
Brian T. Nasipak, Teresita Padilla-Benavides, Karin M. Green, John D. Leszyk, Wenjie Mao, Silvana Konda, Saïd Sif, Scott A. Shaffer, Yasuyuki Ohkawa, Yasuyuki Ohkawa, Anthony N. Imbalzano 
17 Jun 2015-Nature Communications
33 Citations
Calcium-dependent pathways, involving calcineurin and PKCβ, regulate skeletal muscle differentiation by controlling chromatin remodelling through Brg1, highlighting the impact of calcium levels on myofibroblast differentiation.
Journal Article•DOI
Gypenosides Ameliorate Carbon Tetrachloride-Induced Liver Fibrosis by Inhibiting the Differentiation of Hepatic Progenitor Cells into Myofibroblasts
Jiamei Chen, Xuewei Li, Yonghong Hu, Liu Wei, Qun Zhou, Hua Zhang, Yongping Mu, Ping Liu 
31 Jul 2017-The American Journal of Chinese Medicine
18 Citations
Not addressed in the paper.
Journal Article•DOI
Differentiation of Fibroblasts Into Myofibroblasts in the Arachnoid Membrane of Moyamoya Disease
Shusuke Yamamoto, Seiji Yamamoto, Takuya Akai, Masakiyo Sasahara, Satoshi Kuroda 
30 Aug 2022-Stroke
3 Citations
Not addressed in the paper.
Open access•Journal Article•DOI
Calcium-Signalling in Human Glaucoma Lamina Cribrosa Myofibroblasts
Mustapha Irnaten, Colm O'Brien 
01 Jan 2023-International Journal of Molecular Sciences
Elevated calcium levels in glaucomatous lamina cribrosa cells lead to myofibroblast differentiation through increased expression of structural proteins, aSMA, and TGF-b, driven by TGF-b and Smad signaling pathways.
Journal Article•DOI
Impact of calcium on healthy lung myofibroblast mobility
Ryan K. Murphy, Scott Ward, Hali Gipson, Nathalie Fowler, Bethel V. Sharma 
01 Jan 2017-Bios
Calcium levels impact healthy lung myofibroblast mobility, influencing migration and death regulation. The study focuses on lung myofibroblasts, indicating a role for calcium in cell behavior.

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