How do crisis cells die?
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Cells in crisis undergo cell death through autophagy, which is triggered by chromosome breakage and transduced by the cGAS-STING pathway . Telomere dysfunction specifically triggers autophagy, implicating a telomere-driven autophagy pathway that is not induced by intrachromosomal breaks . Activation of autophagy is critical for cell death, as its suppression promoted bypass of crisis, continued proliferation, and accumulation of genome instability . The mechanism of cell death during crisis involves spontaneous mitotic arrest, resulting in death during mitosis or in the following cell cycle . This phenotype is induced by loss of p53 function and is suppressed by telomerase overexpression . Telomere fusions triggered mitotic arrest in p53-compromised non-crisis cells, indicating that such fusions are the underlying cause of cell death .
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10 Citations | Cells in telomere crisis undergo cell death through autophagy, which is triggered by chromosome breakage and transduced by the cGAS-STING pathway. |
249 Citations | The paper states that autophagy, specifically triggered by telomere dysfunction, plays a dominant role in the death of cells during crisis. Loss of autophagy function is required for the initiation of cancer. |
94 Citations | The paper explains that cells in crisis undergo spontaneous mitotic arrest, resulting in death during mitosis or in the following cell cycle. This is induced by loss of p53 function and is suppressed by telomerase overexpression. |
| The CRISISS cells die through irreparable genomic fragmentation caused by the Cas9 nuclease targeting highly repetitive Alu retrotransposons in the human genome. |
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