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How do medium chain triglycerides work alongside polyphenols?

Lipid metabolism

Interesterified fat

Mitochondrial biogenesis

Lipid Metabolism Disorder

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Medium Chain Triglycerides (MCT) and plant polyphenols have complementary effects on lipid metabolism. MCT, containing medium-chain fatty acids, are known to enhance exercise performance by upregulating mitochondrial biogenesis and metabolism through Akt and AMPK signaling pathways while inhibiting TGF-β signaling . On the other hand, plant polyphenols play a crucial role in regulating lipid profiles by influencing cholesterol absorption, triglyceride synthesis, and LDL oxidation . Combining MCT with polyunsaturated fatty acids in structured lipids can further enhance the nutraceutical benefits of MCT, making them suitable for various food and pharmaceutical formulations . Therefore, the synergistic action of MCT and plant polyphenols can potentially aid in preventing metabolic conditions like obesity, hyperlipidemia, and diabetes .

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Open access•Journal Article•DOI Triglycerides of medium-chain fatty acids: a concise review Harsh B. Jadhav, Uday S. Annapure - Show less +1 more 22 Jun 2022-Journal of Food Science and Technology-mysore 12 Citations	Medium-chain triglycerides (MCT) can be combined with polyunsaturated fatty acids to create structured lipids, enhancing nutraceutical benefits and food applications, as discussed in the paper.
Open access•Journal Article•DOI Medium Chain Triglycerides enhances exercise endurance through the increased mitochondrial biogenesis and metabolism. Ying Wang, Zhenzhen Liu, Yi Han, Jiping Xu, Wen Huang, Zhao-Shen Li - Show less +5 more 08 Feb 2018-PLOS ONE 39 Citations	Not addressed in the paper.
Open access•Journal Article [Review: plant polyphenols modulate lipid metabolism and related molecular mechanism]. Yan-li Dai, Yu-xiao Zou, Fan Liu, Hong-zhi Li - Show less +3 more 01 Nov 2015-China journal of Chinese materia medica 2 Citations	Not addressed in the paper.
Patent Use of medium-chain triglycerides for the management of metabolic conditions Mounier Catherine, Rial Sabri - Show less +1 more 14 Jun 2018	Not addressed in the paper.

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Related Questions

Can medium chain triglycerides help burn "deep fat"?5 answersMedium-chain triglycerides (MCTs) have shown promise in aiding fat burning, particularly in reducing body fat accumulationand increasing fat oxidation during physical activity. Research suggests that MCT consumption can lead to greater losses of adipose tissue and body weight, especially in individuals with higher body mass index (BMI). Studies have demonstrated that long-term ingestion of MCTs can significantly reduce body weight and fat, with a more pronounced effect on individuals with a BMI of 23 kg/m² or higher. MCTs are absorbed directly into the portal vein, promoting rapid transport to the liver for oxidation, potentially aiding in the reduction of deep fat stores. Therefore, incorporating MCTs into the diet may indeed help in burning "deep fat" by enhancing fat oxidation and reducing body fat accumulation.

What's the most specie of Triglyceride?5 answersThe most prevalent species of triglyceride identified in research includes triunsaturated triglycerides, with erucic acid being a characteristic component found in the main triglycerides. These triglycerides predominantly consist of 3, 4, or 5 unsaturations, with specific combinations such as C 22:1 C 18:3 C 22:1, C 22:1 C 18:2 C 22:1, and C 22:1 C 18:3 C 18:3 being among the most abundant species observed. Additionally, studies on various plant species have revealed a wide range of triglyceride compositions, with seed fats from different plant families showing diverse triglyceride profiles based on carbon number distributions. Understanding the prevalence and composition of different triglyceride species is crucial for nutritional assessments, disease research, and biochemical mechanism elucidation related to lipid metabolism and health outcomes.

How do medium chain triglycerides improve digestion?5 answersMedium-chain triglycerides (MCTs) improve digestion through various mechanisms. MCTs are easily digested and absorbed, making them a quick energy source. When MCTs are incorporated into structured lipids like EPA-rich medium- and long-chain triacylglycerol (MLCT), they enhance the rate and extent of lipase-mediated digestion, promoting the rapid production of fatty acids. Compared to long-chain triglycerides, MCTs have lower caloricity and higher osmolality, making them beneficial for individuals with digestive disturbances. In infant formulas, MCTs play a crucial role in providing medium-chain fatty acids (MCFAs) for infants with special fat absorption needs, although the natural MCFAs in human milk are part of medium- and long-chain triacylglycerols (MLCTs). Overall, MCTs facilitate efficient digestion, absorption, and energy utilization, making them valuable for various nutritional and medical applications.

How do triacylglycerols function in plant cells?5 answersTriacylglycerols (TAGs) function in plant cells by serving as a cellular protective mechanism against the accumulation of toxic lipid intermediates, such as polyunsaturated free fatty acids, under adverse environmental conditions. TAGs also play a role in the regeneration of membranes after stress cessation by storing substrates required for membrane synthesis. Additionally, TAG accumulation in vegetative tissues is induced by environmental stresses and helps plants cope with abiotic stress by sequestering toxic lipid intermediates. TAGs are enclosed in lipid droplets (LDs) and plastoglobules (PGs), which capture toxic lipid intermediates and contribute to plant tolerance to environmental stresses. Furthermore, LDs in which TAGs are enclosed serve as subcellular factories for the biosynthesis of bioactive compounds that protect against insects and fungi. Overall, TAGs play a crucial role in lipid remodeling, membrane protection, and stress tolerance in plant cells.

What are the effects of the addition of polyphenols into emulsions?5 answersThe addition of polyphenols into emulsions has various effects. Polyphenols can stabilize high internal phase Pickering emulsions (HIPPEs) and reduce interfacial tension, enhancing wettability at the oil-water interface. Tea polyphenols (TP) can inhibit or promote oxidation of proteins and lipids in emulsions, depending on system conditions. Pickering high internal phase emulsions (HIPEs) stabilized by zein nanoparticles and gum Arabic can protect peach polyphenols, improving their stability during UV irradiation, storage, and heating. Tea polyphenols can inhibit lipid and protein oxidation in emulsions, improving their physical stability during storage. The interfacial region plays a critical role in the antioxidant behavior of polyphenols in emulsions, and understanding their effects on effective concentrations is important for designing effective antioxidative solutions.

What is the triglyceride composition of palm oil in Indonesia?5 answersPalm oil in Indonesia has a triglyceride composition that includes high saturated fatty acids (>50%) and relatively few polyunsaturated fatty acids (<10%).

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