How do nanomaterials affect the sensitivity and specificity of electrochemical biosensors for Parkinson Disease detection?
Best insight from top research papers
Nanomaterials play a crucial role in enhancing the sensitivity and specificity of electrochemical biosensors for Parkinson's disease detection. Functionalized nanomaterials, such as gold nanoparticles, carbon nanotubes, and metal oxide nanoparticles, offer increased electron transport, high surface area, and strong adsorption capacity, leading to improved sensor performance . Nanomaterial-based electrochemical sensors, like [email protected]2O3 nanoparticles, exhibit high sensitivity and selectivity for detecting dopamine, a key biomarker in Parkinson's disease . These sensors enable the detection of dopamine at low concentrations with excellent anti-interference ability, showcasing their potential for accurate diagnosis in early stages of the disease. The integration of nanomaterials in biosensors not only enhances sensitivity but also addresses the need for cost-effective and efficient diagnostic technologies for Parkinson's disease detection .
Answers from top 5 papers
More filters
| Papers (5) | Insight |
|---|---|
| Nanomaterials enhance sensitivity and specificity of electrochemical biosensors for Parkinson's Disease by providing high surface area, excellent conductivity, and rapid neurotransmitter detection capabilities. | |
01 Jan 2023 | Nanomaterials enhance sensitivity and specificity in electrochemical biosensors for disease detection by functionalization with receptor molecules, improving biomarker detection for Parkinson's Disease diagnosis. |
| Nanomaterials like gold nanoparticles, carbon nanotubes, and graphene enhance sensitivity in electrochemical biosensors for α-synuclein detection in Parkinson's disease, achieving sub-picomolar detection limits. | |
22 Feb 2023 | Nanomaterials enhance sensitivity and specificity of electrochemical biosensors for dopamine detection, crucial in Parkinson's disease diagnosis, by improving adsorption, electron transport, and surface area. |
1 Citations | AuPd@Fe2O3 nanoparticles enhance sensitivity and selectivity in electrochemical sensors for dopamine detection, crucial in diseases like Parkinson's. They enable precise detection with high sensitivity and anti-interference capabilities. |
Related Questions
How surface modifications affects the sensitivity of an electrochemical sensor?5 answersSurface modifications play a crucial role in influencing the sensitivity of electrochemical sensors. Various studies have highlighted the impact of surface modifications on sensor performance. For instance, the selection of appropriate modifiers can optimize chemical and physical properties, affecting sensor sensitivity. Physical modifications, such as patterning silicon microcantilever surfaces using femtosecond laser micromachining, can enhance sensitivity by increasing the quality factor and specific surface area. Additionally, physical modifications like dip coating with functionalized multi-walled carbon nanotubes have shown significant improvements in lowering the limit of detection for DNA sensing, showcasing the potential of physical modifications in enhancing sensor sensitivity. These findings underscore the importance of surface modifications in tailoring electrochemical sensors for improved sensitivity in various applications.
What are the disadvantages of using nanomaterials for optical biosensors?5 answersThe disadvantages of using nanomaterials for optical biosensors include challenges related to biocompatibility, cytotoxicity, and stability. Nanomaterials tend to self-agglomerate, affecting their properties and stability, which can hinder their performance in biosensors. Additionally, the cytotoxicity of nanomaterials poses severe hazards in biological applications, raising concerns about their safety and potential negative impacts on cells. Despite the unique properties of nanomaterials that make them suitable for biosensors, these challenges need to be addressed to ensure their safe and effective use in optical biosensing applications.
What is the advantages of using znic oxide nanostructures in develoing biosensors?5 answersZinc oxide (ZnO) nanostructures offer several advantages in the development of biosensors. Firstly, ZnO nanostructures possess fascinating properties, including biosafety and biocompatibility, making them suitable for biomedical sciences and healthcare monitoring. Secondly, ZnO nanostructures can be used as biosensor diagnostic tools for point-of-care applications, allowing for disease identification and therapeutics. Thirdly, the integration of ZnO nanostructures in microfluidic biosensors enhances their sensing capabilities, providing advantages such as biocompatibility, high sensitivity and selectivity, and high surface area for surface functionalization. Additionally, ZnO nanostructures have been extensively studied for their extraordinary structural, optical, and electronic properties, making them suitable for diverse applications in photonics, electronics, drug delivery, and bio-imaging. Overall, the use of ZnO nanostructures in biosensors offers the potential for highly rapid, sensitive, stable, selective, and novel devices.
How has the integration of nanotechnology and biotechnology impacted the development of ultra-sensitive biosensors for disease diagnosis?4 answersThe integration of nanotechnology and biotechnology has had a significant impact on the development of ultra-sensitive biosensors for disease diagnosis. Nanomaterials, such as gold nanoparticles, carbon nanotubes, and graphene, have been utilized in the design of biosensors, enabling highly sensitive detection of disease-specific biomarkers. Nanobiosensors, which combine nanotechnology and traditional biosensors, offer improved sensitivity and repeatability compared to traditional biosensors. The use of nanotechnology in biosensors has also facilitated the miniaturization, portability, and wearability of these devices, making them more suitable for clinical medicine applications. Additionally, nanotechnology has allowed for the alteration of molecular properties of materials, such as gold, silver, carbon, silica, and polymers, leading to the development of reliable and accurate diagnostic techniques. The advancements in nanoscale biosensing technologies have enabled high testing throughput without compromising detection resilience, making them valuable tools for disease monitoring. Overall, the integration of nanotechnology and biotechnology has enhanced the sensitivity and accuracy of biosensors, paving the way for improved disease diagnosis and prognosis.
How can PpDA and gold nanoparticles be used for biosensing?4 answersPpDA and gold nanoparticles (AuNPs) can be used for biosensing in various applications. AuNPs possess unique properties such as ease of synthesis, tunable size and shape, lack of acute toxicity, and favorable optical and physicochemical features, making them valuable for biodetection and diagnostics purposes. The synthesis of AuNPs can be achieved through various methods, including sodium borohydride reduction, sodium citrate reduction, mixed reducing agent reduction, and green synthesis. The size, color, and stability of AuNPs can be influenced by factors such as the experimental procedure of synthesis, pH of the medium, mix rate, and other salts in the synthesis medium. Biosensing applications based on AuNPs have been explored in fields such as agriculture, forensic science, analytical calculations, food industry, and biomedical engineering, utilizing principles like surface plasmon resonance, localized surface plasmon resonance, fluorescence, and salt aggregation methods. Additionally, PpDA can act as a growth and capping agent for AuNPs, enhancing the response of a surface plasmon resonance biosensor for the detection of drugs like doxycycline.
What is the use of nanotechnology in pesticide detection?5 answersNanotechnology is being used in pesticide detection to develop more efficient and cost-effective methods. Traditional strategies for pesticide detection involve expensive analytical tools that are not suitable for on-site use and require technical expertise. Nanosensors, which are based on nanomaterials, offer robustness, sensitivity, selectivity, and cost-effectiveness within a miniaturized setup. Various nanomaterials, such as two-dimensional covalent organic frameworks (COFs) and nanostructured gold, have been explored for pesticide detection. COF nanofilms have been used as the lossy layer for terahertz (THz) absorbers, enabling the detection of pesticide residues on the surface of apples. Nanostructured gold-modified electrodes have shown excellent electrochemical sensing performance for organophosphorus pesticides, with applications in real fruit and vegetable samples. Nanotechnology-based approaches offer the potential for rapid and accurate detection of pesticide residues in soil, contributing to environmental protection and sustainable agriculture.