How does heat shock protein expression vary in response to different types of stressors?
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Heat shock proteins (HSPs) exhibit varied expression in response to different stressors. HSPs, ranging from 14 to 120 kDa, are upregulated not only by heat stress but also by anoxia, acidosis, hypoxia, toxins, and microbial infections . In Lymnaea stagnalis, snails with higher basal mRNA levels of HSPs show increased thermal tolerance, indicating a unique response to heat stress . Ostrinia furnacalis expresses different small heat shock proteins in response to environmental stressors, highlighting their regulatory role in stress adaptation . Daphnia magna populations exhibit significant upregulation of HSPs like HSP90 and HSP60 in response to heat shock and mutation accumulation, suggesting a crucial role in stress response and evolution . Additionally, cortisol, estrogen, and nicotine reduce HSP70 expression in oral mucosal keratinocytes, impacting cell viability and potentially contributing to oral lichen planus development .
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| Papers (5) | Insight |
|---|---|
| Heat shock protein expression in O. furnacalis varies based on developmental stage, tissue type, and significantly increases under extreme temperature and UV-A stresses, as shown by the study. | |
| Heat shock protein expression increases significantly in response to thermal stress and mutation accumulation, with a synergistic effect when both stressors are present, supporting their role as stress buffers. | |
20 Sep 2021 | Heat shock protein 70 expression decreases significantly in normal oral keratinocytes when exposed to cortisol, estrogen, and nicotine stressors, impacting cell viability and potentially contributing to oral lichen planus development. |
| In Lymnaea, freshly collected snails have higher basal HSP mRNA levels, potentially indicating higher thermal tolerance, while inbred snails upregulate HSPs in response to specific stressors like heat shock. | |
| Heat shock protein expression varies in response to stressors like anoxia, acidosis, hypoxia, toxins, ischemia, protein breakdown, and microbial infection, not limited to heat-induced stress. |
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