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How does low body fat affect testosterone?

Neuroinflammation

Peripheral nervous system

Androgen deficiency

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Low body fat can impact testosterone levels in men. Research shows that in obese men with low testosterone levels, testosterone treatment alongside weight loss programs can lead to significant reductions in fat mass, particularly visceral fat, while preventing the loss of muscle mass . Additionally, testosterone treatment has been found to reduce leptin levels beyond those achieved by weight loss alone, potentially improving leptin resistance in obese men . However, it is noted that the changes in fat and lean mass resulting from testosterone treatment are not sustained after treatment withdrawal, indicating the need for further studies to assess the long-term benefits and risks of testosterone treatment in obese men .

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Open access•Journal Article•DOI Diet-induced obesity and low testosterone increase neuroinflammation and impair neural function Anusha Jayaraman, Daniella Lent-Schochet, Christian J. Pike - Show less +2 more 16 Sep 2014-Journal of Neuroinflammation 62 Citations	Not addressed in the paper.
Open access•Journal Article•DOI Hypogonadism and male obesity: Focus on unresolved questions. Mathis Grossmann 01 Jul 2018-Clinical Endocrinology 70 Citations	Low body fat can lead to reduced testosterone concentrations due to decreased sex hormone binding globulin levels, potentially affecting the hypothalamic-pituitary-testicular axis and hormone production in men.
Open access•Journal Article•DOI Effect of Testosterone Treatment on Adipokines and Gut Hormones in Obese Men on a Hypocaloric Diet. Mark Ng Tang Fui, Rudolf Hoermann, Mathis Grossmann - Show less +2 more 28 Feb 2017-Journal of the Endocrine Society 15 Citations	Low body fat can lead to decreased testosterone levels. Testosterone treatment in obese men on a hypocaloric diet reduced leptin levels beyond weight loss, potentially reducing leptin resistance.
Open access•Journal Article•DOI Effects of testosterone treatment on body fat and lean mass in obese men on a hypocaloric diet: a randomised controlled trial. Mark Ng Tang Fui, Luke A. Prendergast, Luke A. Prendergast, Philippe Dupuis, Manjri Raval, Boyd Josef Gimnicher Strauss, Jeffrey D Zajac, Mathis Grossmann - Show less +7 more 07 Oct 2016-BMC Medicine 85 Citations	Low body fat can impact testosterone levels, as seen in the study where testosterone treatment during weight loss primarily reduced body fat, potentially influencing testosterone levels positively.
Open access•Dissertation Effect of testosterone therapy combined with a very low caloric diet in obese men: a randomised controlled trial Ng Tang Fui, Mark Andrew - Show less +1 more 01 Jan 2017 4 Citations	Testosterone therapy combined with a very low caloric diet in obese men led to reduced fat mass, improved body composition, and alleviated constitutional symptoms, enhancing testosterone levels.

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