How does malt1 influence antigen presentation?
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MALT1 influences antigen presentation by promoting the turnover of the antigen-loaded MHC-I complex and reducing antigen presentation on tumor cells . It does this by promoting the endocytosis of tumor antigens through direct interaction with the MHC-I complex and endosome-associated RAB proteins . MALT1 is also involved in the activation of the IKK/NF-kappaB pathway, which is essential for antigen receptor-induced NF-kappaB activation . The CBM complex, formed by the assembly of CARMA1, BCL10, and MALT1, recruits and activates the IKK complex, leading to the phosphorylation and degradation of the NF-kappaB inhibitor IjB . Additionally, MALT1 cleaves negative regulators of NF-kappaB signaling, such as A20 and RelB, further promoting NF-kappaB activation . These findings suggest that MALT1 plays a crucial role in regulating antigen presentation and NF-kappaB signaling in lymphocytes .
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| Papers (5) | Insight |
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51 Citations | MAL2, not MALT1, influences antigen presentation by promoting the endocytosis of tumor antigens and reducing the expression of the antigen-loaded MHC-I complex on the cell surface. |
7 Citations | The provided paper does not specifically mention how MALT1 influences antigen presentation. |
| The provided paper does not mention anything about how Malt1 influences antigen presentation. | |
| The provided paper does not mention how MALT1 influences antigen presentation. | |
| The provided paper does not mention how MALT1 influences antigen presentation. |
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