Search or ask a question

How does the combination of melatonin and magnesium glycinate affect the quality of sleep and overall well-being?

Diabetes mellitus

Cochrane Library

Best insight from top research papers

The combination of melatonin and magnesium has shown positive effects on sleep quality and overall well-being in various conditions. Studies have demonstrated that melatonin supplementation improves sleep quality by promoting efficient, deeper, and longer sleep without causing fatigue . Additionally, melatonin in combination with magnesium has been found to significantly reduce testosterone concentrations, serum insulin levels, cholesterol, LDL-C, and HOMA-IR in women with PCOS, indicating an improvement in metabolic profile . Furthermore, melatonin has been shown to be effective in improving sleep quality and reducing disease activity in patients with rheumatoid arthritis, leading to better overall well-being . Therefore, the combination of melatonin and magnesium can positively impact sleep quality and overall health by regulating hormonal levels, improving metabolic parameters, and enhancing sleep patterns.

Answers from top 4 papers

PDF

Open Access

More filters

Papers (4)	Insight
Open access•Journal Article•DOI Effect of melatonin on quality of life and symptoms in patients with cancer: a systematic review and meta-analysis of randomised controlled trials Rong-rong Fan, X. K. Bu, Siyu Yang, Yan Tan, Tongyu Wang, Hongyun Chen, Xuying Li - Show less +6 more 01 Sep 2022-BMJ Open 2 Citations	Not addressed in the paper.
Open access•Journal Article•DOI Metabolic and hormonal effects of melatonin and/or magnesium supplementation in women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial. Mohammad Alizadeh, Majid Karandish, Mohammad Asghari Jafarabadi, Mohammad Asghari Jafarabadi, Lida Heidari, Roshan Nikbakht, Hossein Babaahmadi Rezaei, Reihaneh Mousavi - Show less +7 more 06 Jun 2021-Nutrition & Metabolism 9 Citations	Combining melatonin and magnesium improves sleep quality and hormonal balance in women with PCOS, enhancing overall well-being by reducing testosterone levels and improving metabolic parameters.
Open access•Journal Article•DOI Magnesium and Melatonin Co-Administration Attenuates Blood Glucose Levels in Streptozotocin-Induced Diabetic Rats 30 Jan 2022-Saudi journal of medical and pharmaceutical sciences	Combining melatonin and magnesium can lower blood glucose levels in diabetic rats. However, the impact on sleep quality and overall well-being was not addressed in the study.
Open access•Journal Article•DOI Effect of Melatonin on the Sleep Quality: A Systematic Review Khadijeh Alizadeh Feremi, Lale Alipoor, Ravanbakhsh Esmaeili - Show less +2 more 01 Jun 2021-Reviews in Clinical Medicine	Not addressed in the paper.

My columns

Related Questions

What are the effects of taking a magnesium glycinate supplement?5 answersTaking a magnesium glycinate supplement can have various beneficial effects on health. Magnesium is essential for numerous bodily functions, including glycolysis, energy production, bone development, and potassium/calcium ion transport. Research indicates that magnesium supplementation can lead to improvements in insulin sensitivity and glucose metabolism in individuals with diabetes or at high risk of diabetes. Additionally, magnesium supplementation has been linked to a reduction in inflammatory markers like C reactive protein (CRP) and an increase in nitric oxide levels, which are important for overall health. Furthermore, in women with polycystic ovary syndrome (PCOS), magnesium supplementation has shown positive effects on quality of life, including physical functioning, emotional wellbeing, and social functioning. Overall, taking a magnesium glycinate supplement may help improve insulin sensitivity, glucose metabolism, inflammatory markers, and quality of life.

Does melatonin improve sleep quality?5 answersMelatonin has been shown to improve sleep quality in various populations. In a study comparing melatonin-containing products, Circadin® demonstrated a prolonged release profile and proven efficacy in improving sleep-onset, sleep maintenance, and overall sleep quality throughout the night. Another study found that melatonin treatment improved postoperative sleep quality, increasing total sleep time and sleep efficiency while decreasing the incidence of poor sleep quality. Additionally, melatonin was found to be effective in improving sleep wake disorders in children with developmental challenges, reducing sleep latency, increasing sleep duration, and decreasing night awakenings and daytime drowsiness. In patients with rheumatoid arthritis, melatonin supplementation improved sleep quality and reduced disease activity and pain intensity. Overall, these studies suggest that melatonin can effectively improve sleep quality in various populations.

How does magnesium regulate the circadian clock?5 answersMagnesium regulates the circadian clock by affecting the period and amplitude of circadian oscillations. Magnesium deficiency in plants and young Arabidopsis thaliana seedlings increases the circadian period and dampens its amplitude in a dose-dependent manner. The increase in circadian period caused by magnesium deficiency is light-dependent but does not depend on active photosynthesis. Mathematical modeling suggests that magnesium affects global transcription/translation levels rather than a single component of the circadian oscillator. Magnesium deficiency can be rescued by supplying sufficient magnesium or by inhibiting translation with cycloheximide. In cyanobacteria, magnesium regulates the phosphorylation and dephosphorylation of KaiC, a protein involved in the circadian clock, by dissociating from and associating with catalytic Glu residues. Magnesium concentration alternation between low and high levels in vitro can create an hourglass timekeeping system. Magnesium ions also act as a cell-autonomous timekeeping component in human cells and unicellular algae, regulating key clock properties and linking rhythmic metabolism to clock-controlled gene expression.

How can magnesium bisglycinate impact sleep?4 answersMagnesium bisglycinate can impact sleep by improving sleep quality and duration. It is a highly bioavailable form of magnesium that is absorbed differently in the intestine, reducing competition with other minerals like calcium and protecting magnesium from binding with dietary substances. Additionally, alterations in peripheral magnesium levels have been associated with sleep disturbances, and optimal magnesium levels are needed for normal sleep regulation. Studies have shown that magnesium supplementation can improve sleep onset latency time and total sleep time in older adults with insomnia. Furthermore, dietary magnesium intake has been found to be associated with a decreased likelihood of daytime falling asleep in women. Overall, magnesium bisglycinate can have a positive impact on sleep by improving sleep quality, duration, and reducing sleep disturbances.

How does magnesium help with sleep?2 answersMagnesium helps with sleep by playing a role in neurotransmitter synthesis and functioning of receptors involved in sleep architecture. Magnesium deficiency has been associated with sleep disorders, and supplementation has been shown to improve sleep quality. Low magnesium status is linked to chronic inflammatory stress, which can contribute to poor sleep quality. A study on elderly individuals found that magnesium supplementation improved insomnia. While the exact mechanism is not fully understood, magnesium's involvement in regulating sleep through NMDA antagonism and GABA agonism is suggested. Further research is needed to determine the definitive cause-effect relationship between magnesium status and sleep quality.

What is the dossage of melatonin in adults to improve the nap quality?5 answersThe dosage of melatonin in adults to improve nap quality is not specified in the abstracts provided.

See what other people are reading

How does the process of setting goals affect an athlete's level of anxiety before and during competition?

Setting goals in sports significantly impacts an athlete's anxiety levels before and during competition. Research indicates that process goals have a substantial effect on task performance and self-efficacy, leading to lower anxiety levels. Moreover, the COVID-19 pandemic has shown that competitive anxiety levels can vary based on the athlete's competitive level, with elite athletes experiencing higher anxiety levels compared to amateur athletes. Additionally, achievement goals, such as task and ego goals, are linked to emotions like excitement, hope, and anxiety, with these relationships being mediated by challenge and threat appraisals, ultimately influencing anxiety levels. Therefore, the process of setting goals not only affects an athlete's performance but also plays a crucial role in managing anxiety levels before and during competition.How may an involvement of Genyo affect the learning environment that is being experienced by Grade 10 students?

Incorporating Genyo into the learning environment experienced by Grade 10 students can have significant implications. Genyo's integration can enhance engagement and learning outcomes by providing hands-on experiences and access to resources not typically available in schools. Additionally, Genyo can promote agentic engagement among students, fostering volition, collaboration, and initiative in their learning process. This approach aligns with the need for a positive psychosocial learning environment in Science education, emphasizing relationships, personal development, and systems maintenance and change. Furthermore, integrating Genyo can address challenges in genetics education by offering practical applications and problem-solving opportunities, improving students' understanding of genetic concepts and inheritance. Overall, Genyo's involvement can positively impact the learning environment by promoting engagement, practical learning experiences, and holistic development among Grade 10 students.Does Genyo have a significant effect on the academic setting of Grade 10 students in terms of academic performance?

Genetic algorithms play a crucial role in analyzing students' academic performance by identifying the most impactful factors. Gamification, incorporating game elements in education, has shown to enhance motivation and academic performance across different educational levels. Additionally, experiential learning approaches have been found to significantly improve academic performance and motivation in Grade 10 students. Birth order has also been linked to academic performance, with significant differences observed between first-born, middle child, last-born, and only child students. Therefore, considering the impact of genetic algorithms, gamification, experiential learning approaches, and birth order on academic performance, it can be inferred that Genyo, if integrated effectively, could have a significant effect on the academic setting of Grade 10 students in terms of academic performance.Why are men more successful than women?

Men tend to be more successful than women in various fields due to several factors highlighted in the research. In entrepreneurship, male entrepreneurs invest more hours and have higher experience levels, leading to better financial performance and growth. In online design platforms like Dribbble, men produce more work, showcase it to a larger audience, and receive more likes, partly due to different positioning strategies in the community. In scientific collaborations, successful male and female scientists exhibit similar collaboration patterns, but women are less likely to adopt successful patterns, show stronger gender homophily, and have a higher dropout rate, impacting their scientific success. These gender disparities stem from a combination of social norms, biases, and individual choices within these professional contexts.How effective is treating femoral neck fractures with cannulated screws in older adults compared to other methods?

Treating femoral neck fractures with cannulated screws in older adults has shown varying effectiveness compared to other methods. Studies have highlighted different approaches and outcomes. One meta-analysis favored femoral neck system (FNS) over cannulated compression screw (CCS) due to superior fracture healing time, lower rates of non-union, osteonecrosis, and internal fixation failure, along with improved hip function and reduced complications. Another study compared cannulated screw combined with medial femoral plate to simple cannulated screw, showing better fracture reduction, Harris score, healing time, and lower internal fixation failure with the combined approach. Additionally, a comparison between partially threaded and fully threaded cannulated screws favored the latter for early functional outcomes in stable femur neck fractures in older patients. Furthermore, the joystick technique assisted closed reduction with cannulated screws demonstrated improved fracture reduction effectiveness and reduced femoral neck shortening.What are the most effective detoxing methods for promoting sleep in individuals with autism?

Behavioral interventions, sleep education, and exogenous melatonin are among the most effective detoxing methods for promoting sleep in individuals with autism spectrum disorder (ASD). Behavioral interventions have shown sustained improvements in child sleep, especially when tailored to individual needs. Sleep education and environmental changes have also been highlighted as effective strategies for addressing insomnia in children with ASD. Additionally, the use of exogenous melatonin has demonstrated positive outcomes in promoting optimal sleep in individuals with ASD. These non-pharmacological interventions, along with lifestyle modifications, form a comprehensive approach to improving sleep quality in individuals with autism, addressing the high prevalence of sleep disturbances in this population.How does the training process for supervisors in corrections differ from that of regular officers?

The training process for supervisors in corrections differs from that of regular officers by focusing on enhancing core correctional practice skills and incorporating more rehabilitative strategies. Supervisor training programs like STICS, EPICS, and STARR aim to improve client outcomes by emphasizing skill development and fidelity to correctional practices. In contrast, regular officer training lacks this rehabilitative focus and primarily centers on managing everyday encounters without a psychological perspective. Supervisors in corrections also face unique challenges such as addressing severe mental illness, disruptive behaviors, and recidivism factors, necessitating sound clinical supervision processes. Effective supervision training in corrections is crucial for building cognitive complexity in psychotherapy practices, enhancing student engagement, and ultimately improving the quality of psychological services for inmates.What is the benefit of metformin for PCOS ?

Metformin, a widely used medication for managing Polycystic Ovary Syndrome (PCOS), offers a multifaceted range of benefits for women suffering from this condition. Primarily, metformin has been shown to significantly reduce body weight and Body Mass Index (BMI), which are crucial factors in managing PCOS symptoms and associated metabolic disorders. It also improves insulin sensitivity, a common issue in PCOS patients, thereby addressing one of the root causes of the syndrome. Furthermore, metformin has been associated with a reduction in fasting blood glucose levels and improvements in lipid profiles, including a decrease in low-density lipoprotein cholesterol (LDL-C), which are important for reducing the risk of cardiovascular diseases. Beyond metabolic improvements, metformin has demonstrated positive effects on reproductive health. It restores ovulation cycles and increases the clinical pregnancy rate in women with PCOS, thus addressing infertility issues that many patients face. Metformin treatment has also been linked to a reduction in miscarriage rates, further supporting its role in improving pregnancy outcomes. Additionally, it has a direct impact on reducing hyperandrogenism, a hallmark of PCOS, by lowering total testosterone and androstenedione levels. On a cellular level, metformin has been found to regulate the expression of genes and proteins related to ferroptosis and oxidative stress, suggesting a novel mechanism through which it improves PCOS conditions by affecting ovarian function and follicle development. It also modulates lipid metabolism, indicating its role in addressing dyslipidemia associated with PCOS. Moreover, metformin has shown potential in improving mental health outcomes, specifically reducing the odds of major depression among PCOS patients, which is significant given the higher prevalence of depression and anxiety in this population. In summary, metformin offers comprehensive benefits for managing PCOS, including metabolic improvements, enhanced reproductive health, and potential mental health benefits, making it a cornerstone in the treatment of PCOS.What are the effect of sleep duration on the academic performance of grade 12 working students?

The impact of sleep duration on the academic performance of grade 12 students is significant. Studies show that insufficient sleep can lead to compromised academic performance. Research indicates that students who obtain adequate sleep have better academic outcomes. Additionally, decreased sleep duration has been linked to working memory difficulties, which can ultimately affect academic performance negatively. Furthermore, the interaction between physical activity and sleep duration plays a role in academic achievement, highlighting the importance of finding the right balance between the two for optimal grades. Therefore, for grade 12 working students, ensuring sufficient sleep duration is crucial to support their academic performance, as it can impact cognitive functions and overall well-being, ultimately influencing their success in school.Is corrective feedback effective in written output?

Corrective feedback in written output has shown effectiveness in improving grammatical accuracy and overall language development. Various types of feedback, such as direct, indirect, and metalinguistic, have been found to yield similar effect sizes in enhancing L2 writers' accuracy over time. Additionally, studies suggest that the use of comparators alongside feedback can lead to improvements in lexical complexity and accuracy of new texts. However, while focused corrective feedback can enhance mastery of specific language rules, it may negatively impact other aspects of language learning, especially with explicit metalinguistic explanations. Overall, the literature supports the notion that corrective feedback plays a crucial role in language classrooms, aiding both teachers and learners in assessing performance and fostering development.Why bilateral stenting is harder than unilateral stenting in hilar biliary obstruction?

Bilateral stenting is considered more challenging than unilateral stenting in hilar biliary obstruction due to the complexity and potential for higher complication rates associated with the procedure. Studies comparing unilateral and bilateral stenting in patients with obstructive hilar cholangiocarcinoma (HCCA) have shown that while both approaches have similar technical success rates, bilateral stenting tends to have a higher total complication rate, including re-obstruction and overall complications. Additionally, endoscopic bilateral stenting for malignant hilar biliary obstruction (MHBO) has been associated with a lower technical success rate compared to unilateral stenting, highlighting the increased difficulty of the bilateral procedure. The challenges of bilateral stenting may stem from the need for precise placement of multiple stents and the potential for increased risks during the procedure.