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How does the length of crypts in colon depend on cell proliferation?

Cellular differentiation

Dimethylhydrazine

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The length of crypts in the colon is intricately linked to cell proliferation dynamics. Studies have shown that the proliferation patterns of cells within crypts significantly influence crypt stability and the progression towards colorectal tumorigenesis. Factors such as the position of mitotic activities within the crypt, influenced by growth factors like epidermal growth factor (EGF) and dimethylhydrazine, play a crucial role in determining crypt size and cell production rates. Additionally, the presence of normal microbial flora has been found to stimulate cell proliferation in colonic crypts, leading to differences in crypt length and cell cycle times between conventional and germ-free animals. These findings collectively highlight the complex interplay between cell proliferation, growth factors, and microbial influences in shaping the length of crypts in the colon.

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Open access•Journal Article Effects of epidermal growth factor and dimethylhydrazine on crypt size, cell proliferation, and crypt fission in the rat colon. Cell proliferation and crypt fission are controlled independently. Hyun-Sook Park, Robert A. Goodlad, Dennis J. Ahnen, Angela Winnett, Peter Sasieni, C. Y. Lee, Nicholas A. Wright - Show less +6 more 01 Sep 1997-American Journal of Pathology 74 Citations	Crypt fission and cell proliferation in the colon are independently controlled. Increased cell proliferation does not directly correlate with crypt length, suggesting other factors influence crypt fission.
Open access•Journal Article Cell proliferation in colonic crypts of germ-free and conventional mice--preliminary report. Nowacki Mr 01 Jan 1993-Folia Histochemica Et Cytobiologica 18 Citations	Crypt length in the colon is longer in conventional mice compared to germ-free mice, indicating that cell proliferation, influenced by normal microbial flora, plays a role in crypt length.
Journal Article•DOI Presence of well-differentiated distal, but not poorly differentiated proximal, rat colon carcinomas is correlated with increased cell proliferation in and lengthening of colon crypts. Christopher J. Barnes, W. Elaine Hardman, Ivan L. Cameron - Show less +2 more 05 Jan 1999-International Journal of Cancer 8 Citations	Crypt length in the colon is influenced by cell proliferation, with increased proliferation correlating with lengthening of colon crypts, particularly in the presence of well-differentiated distal colon carcinomas.
Open access•Journal Article•DOI Patterns of proliferative activity in the colonic crypt determine crypt stability and rates of somatic evolution. Rui Zhao, Franziska Michor - Show less +1 more 13 Jun 2013-PLOS Computational Biology 31 Citations	The length of colonic crypts depends on cell proliferation patterns, with mitotic activities concentrated near the stem cell position delaying mutation accumulation and influencing crypt stability.

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