How does the molecular structure of atelocollagen differ from natural collagen?
Best insight from top research papers
The molecular structure of atelocollagen differs from natural collagen due to modifications and functionalizations. Atelocollagen can be covalently functionalized with vinylbenzyl or methacrylamide residues, creating customizable, cell-friendly UV-cured hydrogel networks with varied properties. Additionally, atelocollagen can act as a template for structured silica, exhibiting a fibrous structure with a smooth surface. Traditional purification methods for atelocollagen involve harsh processes, unlike the biomimetic fabrication methods used for atelocollagen-templated silica. Furthermore, atelocollagen extracted from nonedible porcine tissues shows unique biophysical properties, such as superior springiness in auricle collagen and high hardness in body skin collagen. These modifications and properties distinguish atelocollagen from natural collagen, offering tailored characteristics for various applications.
Answers from top 5 papers
More filters
| Papers (5) | Insight |
|---|---|
| Atelocollagen extracted from specific tissues exhibits varied textural properties compared to natural collagen, showcasing unique springiness, hardness, brittleness, viscosity, and fibril formation based on tissue origin. | |
12 Citations | Atelocollagen is covalently functionalized with monomers like 4 vinylbenzyl or methacrylamide, altering its properties compared to natural collagen, affecting gelation, swelling, and enzymatic degradation characteristics. |
10 Citations | Atelocollagen is a purified form of collagen where telopeptides are removed, altering its molecular structure compared to natural collagen, enhancing biocompatibility and reducing immunogenicity. |
| Atelocollagen lacks telopeptides found in natural collagen, maintaining a triple helical rod-like structure. It serves as a homogeneous template for silica formation, unlike fibril-forming collagen. | |
9 Citations | Atelocollagen lacks telopeptides due to pepsin treatment, making it immunologically safer than natural collagen. This modification preserves biocompatibility while reducing immune reactions. |
Related Questions
Amount of collagen in beans and legumes5 answersBeans and legumes contain varying amounts of collagen. Research on rats fed different bean proteins showed that rats fed raw beans synthesized less collagen compared to those fed casein, a control protein. Another study focused on the effects of Phaseolus vulgaris extract on collagen in diabetic rats, indicating that administration of P. vulgaris reduced collagen accumulation and cross-linking in the rats' tendons. Additionally, a composition involving dolomite or limestone and collagen hydrolysate was developed for encapsulating legume seeds, aiming to enhance plant growth and drought resistance. While beans like Phaseolus vulgaris may impact collagen synthesis and properties, further research is needed to fully understand the collagen content in different beans and legumes.
Why is the collagen molecule streaked by molecular packing?5 answersThe collagen molecule is streaked by molecular packing due to its intricate organization at various levels. X-ray diffraction studies suggest that collagen fibrils exhibit an intermediate level of organization, forming five-stranded ropes. These fibrils are further structured into discrete, rope-like substructures known as microfibrils, with proposed models including 2, 4, 5, 7, and 8-stranded arrangements. Additionally, the collagen molecules within these microfibrils are packed in a quasi-hexagonal manner, resembling a molecular crystal lattice, as revealed by a re-interpretation of X-ray data. Furthermore, the specific packing of collagen molecules, such as in the Smith microfibril model, involves dipole-dipole interactions that contribute to the stability of the native fibril structure. This complex packing arrangement results in the characteristic streaked pattern observed in collagen molecules.
How does the structure of collagen fibers in bone compare to that in arteries?5 answersThe structure of collagen fibers in bone and arteries exhibits distinct characteristics. In bone, collagen fibrils self-assemble in a pseudohexagonal array, providing pathways for mineralization. This mineralized collagen matrix shows increased tensile modulus with higher mineral density, enhancing stress-bearing capabilities. Conversely, in arteries, collagen networks play a crucial role in the tissue's passive biomechanical response to mechanical loads, with collagen fibers exhibiting a wavy shape that uncrimps under tension, contributing to nonlinear mechanical behavior. Engineered arteries display thinner and more loosely packed collagen fibrils compared to native arteries, affecting the mechanical properties of the tissue. Therefore, while collagen in bone facilitates mineralization and superior energy dissipation, arterial collagen's behavior is pivotal for the mechanical response of the tissue to loads.
Is collagen supplementation useful for health or physical activity?5 answersCollagen supplementation has been shown to have beneficial effects on health and physical activity. Studies have demonstrated that collagen consumption can lead to improvements in skin health, including decreased wrinkle formation, increased skin elasticity, and increased hydration. Additionally, collagen supplementation has been found to increase bone strength, density, and mass, improve joint stiffness and mobility, and reduce pain. Collagen peptides combined with resistance training have been shown to promote greater hypertrophy in tendinous and muscular structures compared to resistance training alone. Furthermore, collagen supplementation in conjunction with exercise has been found to improve joint functionality, reduce joint pain, and have certain improvements in body composition, strength, and muscle recovery. These findings suggest that collagen supplementation can be useful for promoting overall health and enhancing physical activity outcomes.
Collagen helps with anti aging efects?4 answersCollagen has been found to have anti-aging effects, particularly in improving skin hydration, elasticity, and reducing wrinkles. Hydrolyzed collagen (HC) supplementation has been shown to significantly improve skin hydration and elasticity compared to a placebo group. Oral disintegrating collagen films have also been found to reduce skin wrinkle depth and number, and increase skin elasticity and density. Collagen-based masks have been developed to provide anti-aging effects by improving skin health, detoxification, and preservation of moisture. Collagen isolated from sea grapes and tempe has shown potential anti-aging effects, including antioxidant and tyrosinase inhibition activities. Collagen treatments have been found to be significant in various clinical studies for skin regeneration, bone defects, wound healing, and other conditions related to collagen deficiency.
Is Matrix Biolage Natural?7 answers