How does the regulation of non-insulin-dependent glucose uptake differ between muscle and adipose tissues?
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Non-insulin-dependent glucose uptake regulation differs between muscle and adipose tissues. In muscle cells, co-culture with adipocytes increases glucose uptake in a dose- and time-dependent manner, while in adipose tissue, insulin-stimulated glucose uptake is suppressed when co-cultured with muscle cells . Insulin primarily stimulates glucose uptake in muscle and adipose tissues by translocating GLUT4 to the cell surface, with PI3K playing a crucial role in this process . Additionally, perivascular adipose tissue (PVAT) has been shown to regulate insulin-stimulated muscle perfusion and glucose uptake in vivo, emphasizing the importance of local PVAT in metabolic physiology and vascular function . Overall, the intricate interplay between different tissues and signaling pathways highlights the complexity of non-insulin-dependent glucose uptake regulation in muscle and adipose tissues.
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| In disease models, insulin stimulates glucose uptake in muscle and adipose tissues, while β3 agonist effects vary. Muscle and brown adipose tissues show increased basal glucose uptake in obesity models. | |
| Not addressed in the paper. | |
10 Jan 2023 | Not addressed in the paper. |
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