How does weight affect dosing of NOACs?
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Weight affects the dosing of non-vitamin K antagonist oral anticoagulants (NOACs). In patients with lower body weight, fixed doses of NOACs can lead to suboptimal plasma concentrations, particularly with dabigatran and rivaroxaban . Dose reduction is recommended for apixaban in patients with body weight ≤ 60 kg . On the other hand, in patients with higher body weight, fixed doses of NOACs can result in higher drug exposure and blood drug levels . The International Society on Thrombosis and Haemostasis suggests that NOACs are safer in patients with body weight ≤ 120 kg (BMI ≤ 40 kg/m2) compared to patients with body weight > 120 kg (BMI > 40 kg/m2) . However, the efficacy and safety of NOACs in patients at the extremes of body weight remain uncertain . More data is needed to determine the optimal dosing of NOACs in patients with extreme body weight changes .
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| Papers (5) | Insight |
|---|---|
| The paper does not provide information on how weight affects dosing of NOACs. The paper focuses on the efficacy and safety of NOACs compared to warfarin across the range of body mass index (BMI) and body weight (BW) in patients with atrial fibrillation (AF). | |
| The provided paper does not discuss the dosing of NOACs (Non-Vitamin K Oral Anticoagulants) or how weight affects their dosing. | |
| The paper states that fixed doses of NOACs result in higher drug exposure in patients with lower BMI and lower blood drug levels in patients with higher BMI. | |
52 Citations | The paper discusses how extremes in body weight may affect the efficacy and safety of non-vitamin K antagonist oral anticoagulants (NOACs). However, it does not specifically mention how weight affects the dosing of NOACs. |
| The paper states that concerns of unintentional underdosing in morbidly obese patients and unintentional overdosing in underweight patients have emerged with NOACs. |
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