How has the understanding of curcumin's bioavailability evolved over time, and what factors have influenced this evolution?
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The understanding of curcumin's bioavailability has evolved significantly over time due to various factors. Initially recognized for its therapeutic potential, curcumin faced challenges like poor solubility and bioavailability . Strategies such as forming molecular complexes with proteins, carbohydrates, lipids, and natural compounds have been explored to enhance its bioactivity and bioavailability . Prodrugs have been designed to overcome limitations like low aqueous solubility, aiming to improve tissue distribution and efficacy . Studies have focused on enhancing curcumin's systemic bioavailability, especially through combinations with bio-enhancers like piperine, known for modulating metabolic enzymes and drug transporters . Kinetic and thermodynamic studies have also been conducted to understand the challenges of curcumin's absorption and to explore ways to improve its bioavailability without complex transformations . These diverse approaches reflect the ongoing efforts to optimize curcumin's bioavailability for enhanced therapeutic outcomes.
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| The study explores the kinetic and thermodynamic aspects of curcumin extraction, highlighting the challenges of its weak bioavailability and the potential for improvement through enhanced formulations or analogs. | |
3 Citations | Research has evolved to address curcumin's poor bioavailability, hindering its clinical potential. Piperine, found in black pepper, shows promise in enhancing curcumin's bioavailability through enzyme modulation and transporter activity. |
| Understanding of curcumin's bioavailability has evolved by exploring molecular complexes with proteins, carbohydrates, lipids, and natural compounds, enhancing bioactivity and bioavailability in biological systems. | |
3 Citations | Understanding of curcumin's bioavailability has evolved through prodrug design, esterification processes, and structural modifications to enhance solubility, aiding in overcoming its limitations and improving tissue distribution. |
| Understanding of curcumin's bioavailability has evolved through formulation advancements like piperine coadministration, micelles, nanoparticles, and liposomes, addressing solubility, permeability, and metabolism challenges for enhanced efficacy. |
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