How is CD39 involved in colorectal cancer?
Best insight from top research papers
CD39 is involved in colorectal cancer by promoting immune exhaustion, impairing antitumor immune activity, and increasing CRC progression . CD39 is upregulated in both primary and metastatic colorectal tumors, suggesting its relevance as a molecular target for T-cell engineering . Tumor-infiltrating T cells in colorectal tumors co-express CD39 along with multiple inhibitory receptors, indicating their exhaustion status . CD39 disruption in T cells using CRISPR/Cas9 technology has been shown to improve the adoptive T cell therapy of colorectal cancer . CD39 disruption, combined with the genetic disruption of the endogenous T cell receptor (TCR), generates triple-knockout T cells that exhibit a functional advantage in recognizing and killing colorectal cancer cells . These findings suggest that targeting CD39 in T cells could be a promising approach for the treatment of colorectal cancer .
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| Papers (4) | Insight |
|---|---|
| CD39 contributes to immunosuppressive activity of T cells and poor prognosis in colorectal cancer. | |
| CD39 is coexpressed with CD103 on cytotoxic T cells in colorectal cancers with low mutation burden, indicating its involvement in identifying neoantigen-specific T cells. | |
| CD39 is found to be a major driver of exhaustion in both primary and metastatic colorectal tumors, making it a potential molecular target for T cell engineering in the treatment of colorectal cancer. | |
| CD39 is found to be the major driver of exhaustion in both primary and metastatic colorectal tumors. |
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