Dina Ruano

TL;DR: MSI and IHC analysis are highly concordant in endometrial cancer, and holds true for cases with subclonal loss of MMR protein expression.

TL;DR: It is demonstrated that these standard molecular techniques can be accurately applied on fine needle cytological aspirates from NSCLC patients and show that all mutations detected in the histological material of primary tumor were also identified in the cytological samples.

TL;DR: Although alterations in synaptic signaling processes may not be the exclusive explanation for the association of heterotrimeric G proteins with cognitive ability, such alterations may prominently affect the properties of neurons in the brain in such a manner that impaired cognitive ability and lower intelligence are observed.

TL;DR: POLE DNA analysis now seems warranted in microsatellite instable CRC, especially in the absence of a causative DNA mismatch repair gene germline variant.

TL;DR: The findings suggest that faulty proofreading may result in loss of MMR and thereby in microsatellite instability in Lynch Syndrome patients.