scispace - formally typeset
Search or ask a question

How is mutational analysis done? 


Best insight from top research papers

Mutational analysis is conducted by systematically seeding small artificial faults into a program to evaluate a test suite's effectiveness in detecting these faults. This process, known as mutation testing, aims to enhance or create test suites by using mutants as test goals. The traditional approach faces scalability challenges, especially in large codebases like Google's, due to the immense computational effort required. To address this, a scalable approach has been proposed, involving incremental mutation testing on changed code during code reviews, mutant filtering to remove irrelevant mutants, and selection based on historical performance of mutation operators. This approach has been empirically validated in a code-review-based setting, demonstrating significantly fewer mutants and improved mutant quality and actionability.

Answers from top 4 papers

More filters
Papers (4)Insight
Mutational analysis is done incrementally on changed code during code review, filtering and selecting mutants based on historical performance of mutation operators to improve quality and actionability.
Mutational analysis is done incrementally on changed code during code review, filtering and selecting mutants based on historical performance to improve quality and actionability.
Open accessPosted Content
3 Citations
Mutation analysis is done incrementally on changed code during code review, filtering and selecting mutants based on historical performance of mutation operators to improve mutant quality and actionability.
Mutational analysis is done by selecting mutants based on Fourier analysis of Boolean functions to identify effective transitions on the output, improving mutation analysis efficiency without compromising performance.

Related Questions

How to determine multiple gene mutation in one cell at the same time?5 answersTo determine multiple gene mutations in a single cell simultaneously, various methods have been developed. One approach involves utilizing a single-cell method that integrates genotypes of somatic alterations found in coding regions of messenger RNAs with matching cell transcriptomes. Another method involves the development of a microfluidic chip for profiling selected cells, enabling precise control of cell/reagent movement and in situ MDA amplification at a single-cell level, thus providing complete information on mutation scenarios. Additionally, a novel technique using clamping PNA and detection PNA probes has been successful in simultaneously detecting multiple mutations and performing a melting curve analysis in qPCR, which can aid in the early diagnosis of cancer and determining treatment prognosis. These methods collectively offer efficient ways to detect and quantify multiple gene mutations in a single cell.
How is mutational analysis done in breast cancer?5 answersMutational analysis in breast cancer involves various approaches such as shallow whole genome sequencing (sWGS) of cfDNA to detect somatic copy number alterations (SCNAs), machine-learning methods to study gene functionality in networks derived from mutation associations, targeted kinome sequencing to assess kinome gene alterations and their impact on disease outcomes, and genomic and transcriptomic profiling to identify mutations in genes like GATA3 and their associations with clinical behavior. Additionally, universal germline testing using whole genome sequencing on DNA from blood or saliva is employed to identify actionable germline mutations in hereditary breast cancer (HBC) genes, impacting clinical decision-making and patient outcomes. These diverse approaches provide insights into the genetic landscape of breast cancer, guiding treatment strategies and identifying potential therapeutic targets.
Why is Mutation in Genetic Algorithms important?5 answersMutation in Genetic Algorithms is crucial as it diversifies the population, enhancing exploration of the search space and improving the evolution process. Genetic algorithms, rooted in natural selection principles, rely on mutation to introduce variability and prevent premature convergence, especially in complex problems with multiple local and global optima. Researchers have been exploring mutation techniques, such as the essential mutation based on mutation bias patterns in plants, to optimize algorithm performance on benchmark functions, showing superior results in terms of solution quality and convergence speed. Additionally, the use of Gaussian mutation has been studied to evolve systems efficiently in optimization tasks, highlighting the significance of mutation in adapting and improving classical algorithms for modern computational challenges.
How to analysis gene data?5 answersGene data analysis involves several methods and platforms. One approach is to use genetic algorithms (GA) to select a subset of genes from microarray data for cancer classification. Another method involves using a heterogeneous scheduling platform to perform assembly line management on gene data analysis tasks, improving load balancing and resource allocation. The spark platform can be utilized to achieve gene data analysis through the execution of comparison with reference genes on an elastic distributed data set RDD, enhancing efficiency and flexibility. Additionally, gene data analysis can be performed using tools like SVM, KNN, and the R program, which can generate differentially expressed genes, gene clusters, and classify observed data. Furthermore, a gene analysis annotation method involves capturing gene data from existing databases, constructing an annotation gene database, and carrying out retrieval and annotation on the standard file to generate analysis reports.
What is the typical pipeline for identification of mutations in cancer genomes?5 answersThe typical pipeline for identification of mutations in cancer genomes involves the use of sequencing technologies and bioinformatic analysis. Whole-exome sequencing (WES) is commonly used to detect functional somatic mutations in tumor samples. RNA-seq, which is primarily used for gene expression analysis, can also be utilized for identifying somatic mutations. The pipeline includes aligning the RNA-seq data using tools like STAR aligner and MuTect2 from GATK, followed by variant calling and annotation. The identified variants are then compared against databases like COSMIC and dbSNP to evaluate their significance. Additionally, the variants identified from RNA-seq data can be compared to those identified from exome sequencing to build a comprehensive set of somatic mutations. This integrated approach of using both RNA-seq and WES data enhances the detection of somatic mutations and broadens the scope of discoveries in cancer genomes.
How to find mutation number in Delhi?10 answers

See what other people are reading

What is microclimate modeling?
5 answers
Microclimate modeling involves the analysis and simulation of fine-scale spatial and temporal environmental variations near the surface. It aims to capture the impact of factors like solar radiation, wind speed, humidity, and plant transpiration on the microclimate. Utilizing numerical methods and computational tools like Computational Fluid Dynamics (CFD), researchers model interactions between the atmosphere, urban surfaces, vegetation, and buildings to understand and optimize microclimate conditions. These models help in assessing the influence of boundary conditions on microclimate formation, providing insights for creating more comfortable urban environments and mitigating issues like Urban Heat Island effect. By incorporating high-resolution data and algorithms, microclimate models offer a more accurate representation of how organisms experience climate variability and change, aiding in ecological analyses and forecasts.
How does variation in the genome affect phenotypic expression in a population?
4 answers
Variation in the genome influences phenotypic expression in populations through a combination of genetic and environmental factors. Genetic drift, selection, recombination, and effective population size impact allele-specific expression (ASE). The genetic basis of phenotypic differences among individuals within populations is crucial for understanding disease resistance and conservation efforts. The human genome reflects accumulated variation over time, affecting phenotypes and diseases globally. In eukaryotic organisms, genome size correlates with traits like body size and development time, indicating phenotypic effects of genomic DNA independent of information content. Phenotypic variation is also influenced by environmentally induced variation (EIV) and stochastic developmental variation (SDV), mediated by epigenetic mechanisms, contributing to phenotype optimization and evolutionary bet-hedging.
What are the advatanges and limitations using experimental evolution approach?
5 answers
Experimental evolution offers valuable insights into evolutionary processes by studying organisms in controlled environments, allowing researchers to observe adaptation, selection, and mutation. Advantages include the ability to identify causal mutations underlying adaptation, compare the contributions of initial genetic variation and new mutations to adaptation, and study cultural evolution dynamics through experiments involving human behavior. However, limitations exist, such as the challenge of quantifying the contribution of new mutations in experiments with sexually-reproducing organisms. Additionally, adaptations in laboratory settings may differ from those in nature, potentially involving mutations that are transient or cannot occur naturally. Despite these limitations, experimental evolution remains a powerful tool for understanding evolutionary mechanisms and constraints.
What are the attributes needed for talent development decision making?
4 answers
The attributes needed for talent development decision-making encompass a broad spectrum of factors, ranging from understanding individual talents and interests to leveraging digital technologies and data mining for informed decisions. Firstly, recognizing the significant influence of talent and interest on students' development is crucial, as these elements are foundational to tailoring education programs that align with their abilities and potential. In the realm of sports, particularly football, the talent development process benefits from a multidimensional approach that includes the use of digital technologies and data mining to better support the transition from junior to senior levels, highlighting the importance of a comprehensive analysis of young athletes' skills and attributes. The intuitive aspect of decision-making, where some individuals possess an innate skill that can be honed with training and practice, also plays a role in talent development. Practical considerations such as transparent selection criteria and the involvement of top management are essential for managing expectations and ensuring the success of talent development programs. Social network services can aid in identifying candidates with desired attributes, demonstrating the utility of technology in talent recommendation and selection processes. Furthermore, attributes identified by youth coaches and talent scouts, including tactical, technical, and psychological attributes, are critical in the talent identification process for youth basketball players, suggesting a holistic multidisciplinary approach to talent scouting. The evaluation of candidates' personality traits, abilities, knowledge levels, and development potential through group decision-making methods underlines the complexity of talent selection and evaluation. Differentiated teaching techniques and equitable instruction are necessary for addressing the diverse needs of all students, indicating the need for adaptable and inclusive talent development strategies. Understanding key issues and factors influencing talent management decision-making is vital for designing effective talent management systems. Lastly, strategic talent management requires decision frameworks to structure decisions, pointing to the necessity of a systematic approach in developing talent management strategies.
How does DNA profiling aid the identification of individuals?
5 answers
DNA profiling plays a crucial role in identifying individuals through the analysis of short tandem repeats (STR) in their DNA profiles. This process involves comparing an individual's DNA profile with data stored in a DNA profile database. The technique of DNA profiling is widely utilized in forensic investigations, establishing accurate results for individual and relationship analysis, crime investigation, and hereditary disorders. The advent of DNA profiling has revolutionized human identification in forensic science, with millions of samples analyzed using microsatellite amplicons (STRs) on national DNA databases. Additionally, advancements in information technology, such as data mining techniques, have further enhanced the accuracy and efficiency of DNA matching for disaster victim identification.
How does online learning impacts the academic performance of students?
4 answers
Online learning significantly impacts students' academic performance. Studies have shown that factors such as instructor-student interaction, peer interaction, social media use, family support, and technical support play crucial roles in determining students' engagement and performance. The transition to virtual classrooms during the COVID-19 pandemic has highlighted the importance of technical, technological, psychological, and physical elements in online learning, which significantly affect students' performance. Post-pandemic analysis reveals that online teaching influences students' learning and academic performance, emphasizing the need for improved teaching strategies and understanding students' behavior for enhanced academic outcomes. Additionally, attendance in online synchronous classes has been found to positively impact students' academic performance, with regular participation correlating with higher final grades.
How does machine learning improve supply chain management efficiency?
5 answers
Machine learning (ML) significantly enhances supply chain management (SCM) efficiency by offering various benefits. ML techniques aid in customer value creation, strategic planning, forecasting, competitive trend analysis, and financial strategies in SCM. Additionally, ML algorithms applied to SCM systems enable visualization, automation, and intelligent management of all supply chain links, reducing operating costs and enhancing responsiveness to market demands. Moreover, ML algorithms help in supplier selection processes by predicting reliable suppliers using supervised learning algorithms like AdaBoost, SVM, and KNN, with AdaBoost showing high accuracy and F1-score. Furthermore, ML algorithms assist in identifying potential risks promptly, preventing financial crises, and promoting overall operational efficiency in supply chains. Overall, ML plays a crucial role in optimizing transport, logistics processes, and inventory management systems in SCM.
What is the influence of college course consideration on selection of the students?
5 answers
College course consideration significantly impacts students' selection process. Students weigh various factors like family, friends, job availability, and personal interests when choosing courses. The process of course consideration involves a transition from a wide array of available courses to a narrowed-down set, with consideration set compositions correlating with subsequent majors. Students rely on diverse sources of information, including fellow students, course descriptions, and instructor profiles, to make informed decisions. Faculty members, although primarily discipline-centered, also consider students in their course content selection process, with some focusing on student needs and learning theories. Understanding students' preferences and needs during course consideration is crucial for shaping informed choices, academic progress, and career decisions.
What are the negative impact of Blockchain in terms of Integration Issues for Manufacturing Companies?
4 answers
Blockchain technology, while offering numerous advantages for manufacturing companies, also presents integration issues. These issues include scalability, flexibility, and cybersecurity limitations. Additionally, the centralized architecture of IoT systems in manufacturing poses challenges such as lack of privacy, security, and appropriate authentication schemes. Despite the potential benefits like self-prediction and self-maintenance brought by Industry 4.0 technologies, concerns persist regarding data security, reliability, adaptability, trust, and privacy in contemporary manufacturing settings. Therefore, integrating blockchain into manufacturing systems may face hurdles related to ensuring data validity protection, communication organization, and process efficiency, highlighting the need to address these negative impacts for successful implementation in the Industry 5.0 framework.
What does GenomeSet mean in genomics?
5 answers
In genomics, a GenomeSet refers to a method of representing genomic region sets as vectors or embeddings using techniques like word2vec. These GenomeSets summarize functional genomics data, defining specific locations of interest in the genome such as regulatory regions or transcription factor binding sites. By utilizing advanced computational approaches, GenomeSets can efficiently classify cell lines, antibodies, or tissue types with high accuracy, even in lower-dimensional spaces, while retaining essential biological information. This approach allows for the interpretation of multiple genomic features simultaneously, aiding in the detection of genetic effects and the discovery of disease-related gene sets that might not be identified through individual data type analysis. Overall, GenomeSets offer a promising and efficient way to analyze and interpret complex genomic data in research and clinical settings.
What are the negative impact of Blockchain in terms of Scalability Issues for Manufacturing Companies?
4 answers
Blockchain technology's scalability issues have negative impacts on manufacturing companies. The limitations in blockchain scalability lead to increased transaction costs, reduced service prices, and underutilization of production capacities in Blockchain-Based Shared Manufacturing (BBSM) systems. These limitations are due to the trade-off between scalability, decentralization, and security in existing blockchain networks. The survey of literature highlights various scalability solutions like caching, side chains, off chains, and deep learning methods to address throughput, block size, cost, and latency issues. Public blockchains like Bitcoin and Ethereum face challenges such as low throughput, high latency, and energy consumption, hindering optimal solutions for businesses. Techniques like lightning network, plasma cash, and hard/soft forks are proposed to enhance transaction speed and tackle scalability issues in blockchain systems.