scispace - formally typeset
Search or ask a question

Answers from top 4 papers

More filters
Papers (4)Insight
Comparison with the pattern of neuron death in human AD suggests that each may represent a distinctly different disease model when used in preclinical trials.
Experimental studies show the dependence that a neuron has on the cell population with which it ultimately connects.
The evidence to date is compatible with the requirement for a second "hit" for a neuron to progress cell cycle initiation and DNA replication to death.
This finding could be relevant in cell replacement studies with animal models featuring spiral ganglion neuron degeneration.