K
Karl Herrup
Researcher at University of Pittsburgh
Publications - 240
Citations - 28104
Karl Herrup is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Cerebellum & Purkinje cell. The author has an hindex of 68, co-authored 228 publications receiving 25609 citations. Previous affiliations of Karl Herrup include University Hospitals of Cleveland & Stanford University.
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Journal ArticleDOI
Neuroinflammation in Alzheimer's disease
Michael T. Heneka,Monica J. Carson,Joseph El Khoury,Gary E. Landreth,Frederic Brosseron,Douglas L. Feinstein,Andreas H. Jacobs,Tony Wyss-Coray,Tony Wyss-Coray,Javier Vitorica,Richard M. Ransohoff,Karl Herrup,Sally A. Frautschy,Bente Finsen,Guy C. Brown,Alexei Verkhratsky,Alexei Verkhratsky,Alexei Verkhratsky,Koji Yamanaka,Jari Koistinaho,Eicke Latz,Eicke Latz,Annett Halle,Gabor C. Petzold,Terrence Town,Dave Morgan,Mari L. Shinohara,V. Hugh Perry,Clive Holmes,Clive Holmes,Nicolas G. Bazan,David J. Brooks,Stéphane Hunot,Bertrand Joseph,Nikolaus Deigendesch,Olga Garaschuk,Erik Boddeke,Charles A. Dinarello,John C.S. Breitner,Greg M. Cole,Douglas T. Golenbock,Markus P. Kummer +41 more
TL;DR: Genome-wide analysis suggests that several genes that increase the risk for sporadic Alzheimer's disease encode factors that regulate glial clearance of misfolded proteins and the inflammatory reaction.
Journal ArticleDOI
RAG-1-deficient mice have no mature B and T lymphocytes
Peter Mombaerts,John Iacomini,Randall S. Johnson,Karl Herrup,Susumu Tonegawa,Virginia E. Papaioannou +5 more
TL;DR: The introduction of a mutation in RAG-1 into the germline of mice via gene targeting in embryonic stem cells is described and it is shown that this mutation either activates or catalyzes the V(D)J recombination reaction of immunoglobulin and T cell receptor genes.
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Targeted Disruption of Mouse EGF Receptor: Effect of Genetic Background on Mutant Phenotype
David W. Threadgill,Andrzej A. Dlugosz,Laura A. Hansen,Tamar Tennenbaum,Ulrike Lichti,Della Yee,Christian LaMantia,Tracy Mourton,Karl Herrup,Raymond C. Harris,John A. Barnard,Stuart H. Yuspa,Robert J. Coffey,Terry Magnuson +13 more
TL;DR: The multiple abnormalities associated with EGFR deficiency indicate that the receptor is involved in a wide range of cellular activities.
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Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis.
Eva Y.-H. P. Lee,Chi-Yao Chang,Nanpin Hu,Yi-Chun J. Wang,Chen-Ching Lai,Karl Herrup,Wen-Hwa Lee,Allan Bradley +7 more
TL;DR: Transfer of the human retinoblastoma (RB) mini-transgene into the mutant mice corrects the developmental defects and shows that Rb is essential for normal mouse development.
Journal ArticleDOI
Deficient cerebellar long-term depression and impaired motor learning in mGluR1 mutant mice.
Atsu Aiba,Masanobu Kano,Chong Chen,Chong Chen,Mark E. Stanton,Gregory D. Fox,Karl Herrup,Theresa A. Zwingman,Susumu Tonegawa,Susumu Tonegawa +9 more
TL;DR: It is concluded that mGLUR1 is required for the induction of LTD and that the ataxic behavior and impaired eyeblink conditioning of the mGluR1 mutant mice are primarily due to deficient LTD.