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How long does the body deposti cocaine to hair folicals? 

Pubic hair
Urinalysis
Pregnancy
Hair analysis
Population
Best insight from top research papers

Cocaine can be detected in hair follicles for an extended period due to its deposition over time. Hair testing is valuable for monitoring regular cocaine users over months to years, as it complements the limited detection window of blood and urine tests. External contamination of hair with cocaine can lead to false positives, affecting the discrimination between active users and non-users. Studies show that cocaine incorporation into hair may occur through various mechanisms, such as sweat and sebum, resulting in significant interindividual differences in detection time and amount. The detection threshold for a single dose of cocaine administered intravenously is estimated to be 25-35 mg, with detection possible for 2-6 months.

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Papers (5)Insight
Open access•Journal Article•DOI
Incorporation of isotopically labeled cocaine and metabolites into human hair: 1. dose-response relationships.
Gary L. Henderson, Martha R. Harkey, Chihong Zhou, Reese T. Jones, Peyton Jacob 
01 Jan 1996-Journal of Analytical Toxicology
130 Citations
Cocaine can be detected in hair for 2-6 months after a single dose, with variability among individuals. Incorporation into hair may involve multiple mechanisms during the hair growth cycle.
Open access•Journal Article•DOI
Cocaine contamination in pubic hair: Analysis of the decontamination method
Guido Romano, Francesca Indorato, Giorgio Spadaro, Salvatore Barbera, Nunziata Barbera 
01 Dec 2014-Egyptian journal of forensic sciences
5 Citations
Cocaine can be detected in pubic hair for up to 60 days after contamination, with in vivo samples showing higher concentrations than in vitro samples, indicating potential penetration via sweat and sebum.
Open access•Journal Article•DOI
External Contamination of Hair with Cocaine: Evaluation of External Cocaine Contamination and Development of Performance-Testing Materials*
Peter Stout, Jeri D. Ropero-Miller, Michael Baylor, John M. Mitchell 
01 Oct 2006-Journal of Analytical Toxicology
69 Citations
Cocaine can persist in hair follicles for at least 21 days post-contamination, as indicated by the study on external cocaine contamination of hair.
Journal Article•DOI
Diagnosing Intrauterine exposure to cocaine by hair testing : Six years of clinical use
Gideon Koren, Julia A. Klein, Kristen I. Mcmartin 
01 Oct 1998-Therapeutic Drug Monitoring
15 Citations
Neonatal hair testing for cocaine reflects maternal addiction during the last 4 months of pregnancy, indicating a timeframe of approximately 4 months for cocaine deposition in hair follicles.
Open access•Journal Article•DOI
A Review of Methodology for Testing Hair for Cocaine
Rebekah Harrison, Shanlin Fu 
01 Jan 2014
13 Citations
Cocaine enters hair during keratinization and remains for months to years. It is not detectable immediately after use, making hair testing suitable for long-term drug monitoring in regular users.

Related Questions

What affects the window of detection for cocaine in hair?5 answersThe window of detection for cocaine in hair is influenced by various factors. Cocaine and its metabolites are not immediately detectable in hair after ingestion, affecting the detection window. The growth rate of hair, approximately half an inch per month, determines the timeframe covered by a hair sample, typically providing a three-month window for drug detection. Different routes of biomarker deposition onto hair, including blood vessels, sebum, sweat, and environmental exposure, contribute to the accumulation of drug residues in the hair matrix, impacting the detection period. Hair testing's ability to reveal a long-term history of drug use, spanning weeks to months, enhances its efficacy in monitoring cocaine exposure over an extended period.
What are the effects of drug addiction on fertility?4 answersDrug addiction can have negative effects on fertility. Illicit drug use, including amphetamines, cocaine, opioids, and marijuana, can result in subfertility or complete infertility in males. Heroin consumption can affect sperm parameters, such as motility and viability, as well as histone-to-protamine transition ratios and semen pH. Drug use, particularly heroin, is associated with higher rates of mortality and morbidity for both mother and baby. Chronic opiate addiction can lead to reduced sexual ability and severe abnormalities, possibly due to hyperprolactinemia. Overall, drug addiction can impair male fertility and have detrimental effects on reproductive health.
How long is hair cortisol stable?5 answersHair cortisol levels have been found to exhibit a high level of intraindividual stability over extended periods of time, ranging from one year to at least four months. In one study, hair cortisol levels were positively correlated from 9 to 12 months in both mothers and infants. Another study showed that hair cortisol concentrations remained stable over a two-month interval. Additionally, hair cortisol levels were found to be stable from 6 to 9 months and 9 to 12 months in mothers and infants. These findings suggest that hair cortisol can be a reliable biomarker for detecting long-term cortisol secretion and chronic stress experiences. However, hair cortisol levels may vary depending on the time domain being measured, with stronger correlations observed for longer periods of time. Overall, hair cortisol appears to provide a stable measure of cortisol levels over extended periods, making it a valuable tool for assessing chronic stress.
How does the presence of drugs such as cocaine in a body affect the decomposition of the body?4 answersThe presence of drugs such as cocaine in a body can affect the decomposition process. In a case study of a body packer who died from cocaine intoxication, internal examinations revealed edema and generalized congestion of the organs. Another study reported a fatal cocaine poisoning in a body stuffer, where the body had extremely high plasma concentrations of cocaine and its metabolites. The autopsy findings, combined with the toxicological information, were essential in determining cocaine poisoning as the cause of death. These findings suggest that the presence of cocaine in the body can lead to changes in organ congestion and edema, which may impact the decomposition process. However, further research is needed to fully understand the specific effects of cocaine on body decomposition.
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