How PKR is related to ADAR 1?
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PKR and ADAR1 are both involved in the response to viral infections. ADAR1 is an RNA deaminase that plays a role in regulating mRNA translation and is induced by interferon (IFN)-I. PKR, on the other hand, is a kinase that is activated by double-stranded RNA (dsRNA) and is also induced by IFN-I. Both PKR and ADAR1 have been shown to have opposite effects on HTLV replication, with ADAR1 enhancing HTLV infection and PKR inhibiting it . Additionally, PKR has been found to be a central component of immunopathology in a mouse model of ADAR AGS mutation, and inhibition of the integrated stress response downstream of PKR phosphorylation prevents disease progression . Furthermore, PKR and ADAR1 have been shown to interact with each other, and the binding of ADAR1 to PKR may contribute to PKR dephosphorylation during HIV-1 replication .
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| Papers (4) | Insight |
|---|---|
| PKR interacts with ADAR1 in the absence of RNAs, suggesting that ADAR1 and PKR are related in the context of HIV-1 replication. | |
| PKR is inhibited by ADAR1, which enhances HTLV-1 and HTLV-2 replication. ADAR1 expression suppresses PKR phosphorylation, leading to increased viral protein translation. | |
| PKR is an essential IFN-dependent effector that mediates disease manifestations and mortality in ADAR1-mutant mice. | |
15 Jun 2022 | PKR is inhibited by ADAR1p110 through its double stranded RNA binding domains (dsRBDs), leading to decreased PKR phosphorylation and increased viral replication. |
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