How temperature influence on heart cells?
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Temperature has a significant influence on heart cells. Lowering the temperature decreases force development, extent of shortening, and velocity of shortening in cardiac cells . In neonatal rat hearts, the conductance of gap junctions (gj) between cells is positively correlated with temperature. Cooling from 37°C to 14°C leads to a steeper decrease in gj, while cooling from 14°C to -2°C leads to a shallower decrease. This suggests that gj may be controlled by enzymatic reactions . Permanent treatment with adrenaline at raised temperatures leads to a decrease in cell counts and an increase in lactate, LDH, α-HBDH, and GOT, indicating an injured membrane function of rat heart cells . Rhythmically contracting single heart cells from hibernating and non-hibernating animals continue to beat at 0°C, indicating that low temperature does not affect their response . Overall, temperature affects the electrical properties, contractile behavior, and membrane function of heart cells.
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| Papers (5) | Insight |
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| The paper discusses the effects of temperature on cardiac tissue dynamics, including restitution, conduction velocity, and alternans regimes. It describes how temperature variations can lead to proarrhythmic behavior in the heart. | |
11 Citations | The paper states that the response of single heart cells to temperature decrease varied greatly. Some cells from both hibernating and non-hibernating species continued to beat at 0°C. |
1 Citations | The paper discusses the effect of temperature on the mechanical behavior of single skinned cardiac cells. Lowering the temperature decreases force development, extent of shortening, and velocity of shortening. The effects on calcium sensitivity of velocity of shortening are more pronounced than the effects on calcium dependence of force and extent of shortening. |
49 Citations | The paper discusses the influence of temperature on the electrical properties of gap junctions in neonatal rat heart cells. It shows that temperature affects the conductance of the junctional membranes and the single gap-junction channels. |
| The paper states that raised temperature sensitizes rat heart cells to adrenaline treatment, leading to a decrease in cell counts and an increase in lactate production. |
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