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How the high calloric diets affect neuroinflamation on hippocampus?

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High-caloric diets, particularly those high in fat and sugar, have been shown to induce neuroinflammation in the hippocampus. These diets can lead to cognitive decline, memory impairment, and alterations in neurotransmission systems involved in memory regulation. The neuroinflammatory response in the hippocampus includes glial activation, alterations in glutamatergic function, and increased levels of pro-inflammatory molecules. Additionally, high-caloric diets have been linked to a reduction in neurogenesis and an increase in markers of cellular senescence, potentially contributing to cognitive decline. The effects of these diets on the hippocampus can be exacerbated in aging individuals, leading to impaired spatial learning, memory, and increased anxiety levels. Overall, high-caloric diets can have detrimental effects on hippocampal function through the induction of neuroinflammation and related processes.

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Journal Article•DOI Abscisic Acid Supplementation Rescues High Fat Diet-Induced Alterations in Hippocampal Inflammation and IRSs Expression Alberto Ribes-Navarro, Mariam Atef, Sandra Sánchez-Sarasúa, María Teresa Beltrán-Bretones, Francisco E. Olucha-Bordonau, Ana María Sánchez-Pérez - Show less +5 more 01 Jan 2019-Molecular Neurobiology 22 Citations	High-fat diet induces hippocampal neuroinflammation, reducing IRS2 expression and increasing IRS1, TNFα, and APP levels, while decreasing BDNF and neurogenesis. Abscisic acid supplementation rescues these alterations.
Book Chapter•DOI Neurochemical Effects of Long Term Consumption of High Fat Diet Akhlaq A. Farooqui 01 Jan 2015 2 Citations	High fat diets induce neuroinflammation in the hippocampus through mechanisms like ER stress, mitochondrial dysfunction, and insulin resistance, negatively impacting cognitive function and glucose transport mechanisms.
Open access•Journal Article•DOI Effects of High-Fat and High-Fat High-Sugar Diets in the Anxiety, Learning and Memory, and in the Hippocampus Neurogenesis and Neuroinflammation of Aged Rats Bárbara Mota, Miguel Ramos, Sandra I. Marques, Ana Silva, Pedro A. Pereira, Maria Dulce Madeira, Nuno Mateus, Armando Cardoso - Show less +7 more 01 Mar 2023-Nutrients	High-fat high-sugar diets increase neuroinflammation in the hippocampus of aged rats, as evidenced by elevated levels of glial fibrillary acidic protein (GFAP) cells.
Open access•Journal Article•DOI Chronic consumption of a hypercaloric diet increases neuroinflammation and brain senescence, promoting cognitive decline in middle-aged female Wistar rats Verónica Salas-Venegas, Roberto Santín-Márquez, Ricardo Jair Ramírez-Carreto, Yesica María Rodríguez-Cortés, Agustina Cano-Martínez, Armando Luna-López, Anahí Chavarría, Mina Konigsberg, Norma Edith López-Diazguerrero - Show less +8 more 17 Apr 2023-Frontiers in Aging Neuroscience	Chronic consumption of a hypercaloric diet induces neuroinflammation in the hippocampus, contributing to cognitive decline in middle-aged female Wistar rats, as shown in the study.
Open access•Posted Content•DOI Chronic Hyperpalatable Diet Impairs Hippocampal-dependent Memories by Disrupting Glutamatergic and Fractalkine Axis Signaling 03 May 2023	Chronic hyperpalatable diets can induce hippocampal glutamatergic dysfunction and memory impairment without causing neuroinflammation, possibly through modulation of fractalkine levels to counter glutamatergic toxicity.

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