How to enhance the solubility of bcs class II drugs for wound healing action?
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To enhance the solubility of BCS class II drugs for wound healing action, various techniques can be employed. One effective method is the formulation of solid dispersions using hydrophilic carriers like Gelucire 50/13 or PVP K30. Another approach is the utilization of liquisolid technology, which involves converting the drug into a liquid form using non-volatile solvents and carriers like Avicel PH 102. Additionally, the use of polymeric nanomicelles, such as Soluplus®, can significantly improve the apparent solubility of BCS class II drugs like ibuprofen, idebenone, and miconazole, thereby aiding in wound healing applications. These methods enhance solubility, dissolution rates, and bioavailability, crucial for effective wound healing treatments.
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| Papers (5) | Insight |
|---|---|
| Solubility of BCS class II drugs like Apixaban can be enhanced for wound healing by formulating solid dispersions with hydrophilic polymers like HPMC E50 LV and PEG 6000 using solvent evaporation. | |
| Soluplus® polymeric nanomicelles can enhance solubility of BCS class II drugs like ibuprofen, idebenone, and miconazole, potentially aiding wound healing through improved drug solubility. | |
2 Citations | Solid dispersion using Gelucire 50/13 as a carrier can enhance solubility of BCS class II drugs like ambrisentan, improving bioavailability for potential wound healing applications. |
| Nanodispersion technology with PVP K30 and poloxamer 407 can enhance solubility of BCS class II drug zaltoprofen, potentially aiding wound healing due to improved drug release and anti-inflammatory effects. | |
12 Jan 2023 | Liquisolid technology, utilizing polyethylene glycol 400, Avicel PH 102, and Aerosil 200, significantly enhances solubility and dissolution of BCS class II drugs like mosapride citrate, potentially aiding wound healing. |
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