How to synthesisze N substituated Benzoyl hudrazide?
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To synthesize N-substituted benzoyl hydrazide, one method involves acylating benzoyl hydrazine with stearyl chloride to obtain N-(benzoyl) stearic acid hydrazide, achieving a high yield of 92.9% under optimized conditions of a 1:1 molar ratio, 6 hours reaction time, and 70°C temperature . Another approach utilizes 2,2'-dithiodibenzoic acid and triphosgene to acylate chlorinate, followed by reacting the resulting 2,2'-dithiodibenzoyl chloride with an amine compound and performing a disproportionation cyclization reaction under alkaline conditions to obtain an N-substituted benzo-isothiazolone derivative with high selectivity, conversion rate, yield rate, and purity, suitable for industrial production . Both methods offer efficient routes for synthesizing N-substituted benzoyl hydrazide derivatives with good yields and potential industrial applications.
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| The synthesis of N-substituted benzoyl-hydrazides can be achieved by reacting carboxylic acids with N,N'-disubstituted carbodiimides under solvent-free conditions, either using microwave radiation or dry heating. | |
Open access•Journal Article 4 Citations | Not addressed in the paper. |
| N-(Benzoyl) stearic acid hydrazide was synthesized from benzoyl hydrazine and stearyl chloride via acylation. Optimal conditions were molar ratio 1:1, 6h reaction time, and 70°C temperature, yielding 92.9%. | |
| The synthesis of N-substituted benzoyl hydrazide involves a simple method with mild conditions, resulting in high yields. The process is suitable for industrial production with significant biological activity. | |
| Not addressed in the paper. |
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