R
Ronaldo N. de Oliveira
Researcher at Universidade Federal Rural de Pernambuco
Publications - 54
Citations - 734
Ronaldo N. de Oliveira is an academic researcher from Universidade Federal Rural de Pernambuco. The author has contributed to research in topics: Cycloaddition & Catalysis. The author has an hindex of 13, co-authored 51 publications receiving 558 citations. Previous affiliations of Ronaldo N. de Oliveira include Lyon College & Claude Bernard University Lyon 1.
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Journal ArticleDOI
Potent naphthoquinones against antimony-sensitive and -resistant Leishmania parasites: Synthesis of novel α- and nor-α-lapachone-based 1,2,3-triazoles by copper-catalyzed azide–alkyne cycloaddition
Tiago T. Guimarães,Maria do Carmo F. R. Pinto,Juliane Sousa Lanza,Maria Norma Melo,Rubens L. do Monte-Neto,Isadora M.M. de Melo,Emilay B. T. Diogo,Vitor F. Ferreira,Celso A. Camara,Wagner O. Valença,Ronaldo N. de Oliveira,Frédéric Frézard,Eufrânio N. da Silva Júnior +12 more
TL;DR: One of these compounds exhibited cross-resistance in Sb-resistant Leishmania and could provide a molecular tool for investigating the multidrug resistance mechanisms in Leishmanial parasites.
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1,2,3-Triazole-, arylamino- and thio-substituted 1,4-naphthoquinones: Potent antitumor activity, electrochemical aspects, and bioisosteric replacement of C-ring-modified lapachones
Eduardo H. G. da Cruz,Caio M.B. Hussene,Gleiston G. Dias,Emilay B. T. Diogo,Isadora M.M. de Melo,Bernardo L. Rodrigues,Mauro G. da Silva,Wagner O. Valença,Celso A. Camara,Ronaldo N. de Oliveira,Yen G. de Paiva,Marília O. F. Goulart,Bruno C. Cavalcanti,Cláudia Pessoa,Eufrânio N. da Silva Júnior +14 more
TL;DR: 1,2,3-Triazole-, arylamino- and thio-substituted naphthoquinones (24, 8, and 2 representatives) showed potent cytotoxicity against different cancer cell lines and may represent promising new lead derivatives for anticancer drug development.
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On the search for potential anti-Trypanosoma cruzi drugs: Synthesis and biological evaluation of 2-hydroxy-3-methylamino and 1,2,3-triazolic naphthoquinoidal compounds obtained by click chemistry reactions
Eufrânio N. da Silva Júnior,Isadora M.M. de Melo,Emilay B. T. Diogo,Verenice A. Costa,José Dias de Souza Filho,Wagner O. Valença,Celso A. Camara,Ronaldo N. de Oliveira,Alexandre Suman de Araujo,Flavio da Silva Emery,Marcelo Rodrigues dos Santos,Carlos A. de Simone,Rubem F. S. Menna-Barreto,Solange L. de Castro +13 more
TL;DR: Fifteen substances were identified as more potent than the standard drug benznidazole, with IC(50)/24h values in the range of 10.9-101.5 μM, and two are important structures for further studies.
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Ivermectin: an award-winning drug with expected antiviral activity against COVID-19.
Fabio Rocha Formiga,Fabio Rocha Formiga,Roger M. Leblanc,Juliana de Souza Rebouças,Leonardo P. Farias,Ronaldo N. de Oliveira,Lindomar Pena +6 more
TL;DR: Challenges surrounding the use of ivermectin in the context of coronavirus disease-19 (COVID-19) and how novel formulations employing micro- and nanotechnologies may address these concerns are discussed.
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Synthesis and anti-Trypanosoma cruzi activity of naphthoquinone-containing triazoles: electrochemical studies on the effects of the quinoidal moiety.
Emilay B. T. Diogo,Gleiston G. Dias,Bernardo L. Rodrigues,Tiago T. Guimarães,Wagner O. Valença,Celso A. Camara,Ronaldo N. de Oliveira,Mauro G. da Silva,Vitor F. Ferreira,Yen G. de Paiva,Marília O. F. Goulart,Rubem F. S. Menna-Barreto,Solange L. de Castro,Eufrânio N. da Silva Júnior +13 more
TL;DR: In the continued search for novel trypanocidal compounds, twenty-six derivatives of para- and ortho-naphthoquinones coupled to 1,2,3-triazoles were synthesized and evaluated against the infective bloodstream form of Trypanosoma cruzi, the etiological agent of Chagas disease.