Is CTCFL relate to NSCLC or metastasis? 

CTCFL, also known as NEFL, is related to non-small cell lung cancer (NSCLC) and metastasis. Studies have shown that NEFL expression is associated with decreased lymph node metastases and favorable prognosis in NSCLC patients . Knocked-down of NEFL enhances the invasion and migration of NSCLC cells, while NEFL overexpression suppresses invasion and migration in vitro . NEFL downregulation is associated with promoter methylation, and NEFL expression can be restored after treatment with 5-Aza-dC . NEFL inhibits the NF-κB pathway, thereby suppressing the expression of uPA and decreasing NSCLC invasiveness and migration . Additionally, the EMT phenotype of circulating tumor cells (CTCs) in the peripheral blood of NSCLC patients is associated with distant metastasis. E+/M+ CTCs and M+ CTCs have been identified as potential predictors of distant metastasis in NSCLC patients .

Epithelial circulating tumor cells with a heterogeneous phenotype are associated with metastasis in NSCLC

The provided paper does not mention anything about CTCFL in relation to NSCLC or metastasis.

Methylation of neurofilament light polypeptide promoter is associated with cell invasion and metastasis in NSCLC.

The provided paper does not mention anything about CTCFL in relation to NSCLC or metastasis.

Cerebrospinal fluid circulating tumor DNA depicts profiling of brain metastasis in NSCLC

The provided paper does not mention anything about CTCFL or its relation to NSCLC or metastasis.

p38 pathway as a key downstream signal of CTGF to regulate metastasis potential in NSCLC.

The provided paper does not mention anything about CTCFL or its relation to NSCLC or metastasis.

Epithelial‑mesenchymal transition phenotype of circulating tumor cells is associated with distant metastasis in patients with NSCLC.

The provided paper does not mention anything about CTCFL or its relation to NSCLC or metastasis.