Y
Yoshihiro Hayakawa
Researcher at University of Toyama
Publications - 158
Citations - 16949
Yoshihiro Hayakawa is an academic researcher from University of Toyama. The author has contributed to research in topics: Cancer & Interleukin 21. The author has an hindex of 58, co-authored 155 publications receiving 15408 citations. Previous affiliations of Yoshihiro Hayakawa include Juntendo University & University of Tokyo.
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Journal ArticleDOI
STING is a direct innate immune sensor of cyclic di-GMP
Dara Burdette,Kathryn M. Monroe,Katia Sotelo-Troha,Jeffrey S. Iwig,Barbara Eckert,Mamoru Hyodo,Yoshihiro Hayakawa,Russell E. Vance +7 more
TL;DR: It is demonstrated that STING binds directly to radiolabelled cyclic diguanylate monophosphate (c-di-GMP), and it is shown that unlabelledcyclic dinucleotides, but not other nucleotides or nucleic acids, compete with c-di -GMP for binding to STING.
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Involvement of tumor necrosis factor-related apoptosis-inducing ligand in surveillance of tumor metastasis by liver natural killer cells.
Kazuyoshi Takeda,Yoshihiro Hayakawa,Mark J. Smyth,Nobuhiko Kayagaki,Noriko Yamaguchi,Shigeru Kakuta,Yoichiro Iwakura,Hideo Yagita,Ko Okumura +8 more
TL;DR: It is reported that TRAIL is constitutively expressed on murine natural killer cells in the liver and plays a substantial role in suppressing tumor metastasis and provides the first evidence for the physiological function of TRAIL as a tumor suppressor.
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New aspects of natural-killer-cell surveillance and therapy of cancer
TL;DR: The potential for NK cells to be rationally manipulated in the treatment of human cancers is only recently begun to appreciate.
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CD27 Dissects Mature NK Cells into Two Subsets with Distinct Responsiveness and Migratory Capacity
Yoshihiro Hayakawa,Mark J. Smyth +1 more
TL;DR: It is reported that CD27 is a key marker of the NK cell lineage, dissecting the mature Mac-1high NK cell pool into two functionally distinct subsets that possesses a higher threshold to stimulation and appears to be tightly regulated by the expression of NK cell inhibitory receptors.
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Activation of NK cell cytotoxicity.
Mark J. Smyth,Erika Cretney,Janice M. Kelly,Jennifer A. Westwood,Shayna E. A. Street,Hideo Yagita,Kazuyoshi Takeda,Serani L.H. van Dommelen,Serani L.H. van Dommelen,Mariapia A. Degli-Esposti,Mariapia A. Degli-Esposti,Yoshihiro Hayakawa +11 more
TL;DR: The functional importance of NK cell cytotoxicity and the receptor/ligand interactions that control these processes are discussed, which are important for the pathophysiology of many diseases.