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Is leptin expressed in endometrium? 


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Leptin is expressed in the endometrium .

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Yes, leptin is expressed in the endometrium. The paper states that leptin and its receptors were overexpressed both at the mRNA and protein levels in endometrial tissue samples.
The paper states that leptin receptors are located in the cell membrane or cytoplasm of normal and tumoral endometrial cells, but it does not explicitly mention if leptin itself is expressed in the endometrium.
Yes, leptin is expressed in the endometrium. The study found that leptin expression was significantly higher in the endometrium of women with Polycystic Ovary Syndrome (PCOS) compared to normal women.
The paper does not directly mention if leptin is expressed in the endometrium. The paper focuses on leptin receptor expression in cases of embryo transfer to endometrial coculture.

Related Questions

What is the role of leptin signaling in the endometrium?5 answersLeptin signaling plays a significant role in the endometrium. Leptin, an adipokine produced by adipose tissue, acts via its transmembrane receptors (Ob-R) to regulate various physiological and pathological processes in the endometrium. Leptin has been shown to be involved in endometrial cancerogenesis, with laboratory findings demonstrating its link to neoplastic phenomena such as cellular proliferation, angiogenesis, and estrogenic activity. Leptin receptor expression is triggered by embryo transfer to endometrial coculture, suggesting its involvement in successful implantation. In the context of endometriosis, leptin has been found to contribute to endometriosis-induced pain, with increased levels of leptin observed in endometriosis-like lesions and intramuscular injection of leptin inducing mechanical hyperalgesia. Blocking leptin/OB-R signaling impairs mouse implantation and reduces the expression of molecules involved in endometrial receptivity and successful implantation. Overall, leptin signaling plays a crucial role in the physiology and pathology of the endometrium, including endometrial cancer, implantation, and endometriosis-induced pain.
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What is the role of kisspeptin in endometriosis?4 answersKisspeptin is suggested to play a role in the pathogenesis of endometriosis, but its exact role is still being investigated. Serum kisspeptin levels were found to be significantly different between endometriosis patients and healthy controls, but they were unable to differentiate the severity of endometriosis. In patients with endometriosis, kisspeptin levels were found to be lower in eutopic endometrial stroma compared to women without endometriosis, indicating a potential role for decreased kisspeptin expression in the development of endometriosis. Additionally, deeply invasive lesions showed lower kisspeptin levels compared to superficial lesions, suggesting that downregulation of kisspeptin levels may contribute to the invasiveness of endometriotic implants. Further comprehensive studies are needed to fully understand the role of kisspeptin in endometriosis.
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Does leptin predict complications in n type 2 diabetes?5 answersLeptin levels are related to complications in patients with type 2 diabetes mellitus (T2DM) and affect the prevalence rates of complications. Leptin levels were significantly higher in T2DM patients with microvascular complications compared to those without. Leptin levels were also found to be related to high insulin resistance (IR), atherogenic index of plasma (AIP), and body mass index (BMI) among T2DM female patients. Additionally, reduced leptin mRNA expression levels were significantly associated with T2DM and could be used as a predictive and diagnostic biomarker for T2DM. Leptin levels were significantly higher in diabetic patients with complications, which may be due to the inflammatory properties of leptin and its role in vascular inflammation and endothelial dysfunction. Therefore, leptin levels may serve as a predictor for complications in T2DM patients.