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Is matrix effect observed in secondary neutral mass spectrometer? not SIMS?

Mass spectrometry imaging

Matrix (chemical analysis)

Mass spectrometry

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Matrix effects are commonly observed in secondary ion mass spectrometry (SIMS) techniques, such as Time-of-Flight Secondary Ion Mass Spectrometry (TOF-SIMS) . These effects can significantly impact the ionization efficiency and intensity of analytes, leading to challenges in quantitative analysis. Studies have explored various methods to mitigate matrix effects in SIMS, including in situ matrix-enhanced SIMS approaches . Researchers have investigated the influence of different matrices on ionization efficiency and signal enhancement in SIMS analyses of diverse samples, ranging from biological tissues to organic molecules . Strategies like laser post-ionization have been proposed to reduce matrix effects and improve depth profiling in SIMS analyses of organic molecules . Therefore, while matrix effects are prevalent in SIMS, efforts are ongoing to address and minimize their impact on analytical outcomes.

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Open access•Journal Article•DOI The matrix effect in TOF-SIMS analysis of two-element inorganic thin films Agnieszka Priebe, Tianle Xie, Tianle Xie, Gerhard Bürki, Laszlo Pethö, Johann Michler - Show less +5 more 10 Jun 2020-Journal of Analytical Atomic Spectrometry 22 Citations	Not addressed in the paper.
Journal Article•DOI Reducing the Matrix Effect in Molecular Secondary Ion Mass Spectrometry by Laser Post-Ionization Lars Breuer, Nicholas J. Popczun, Andreas Wucher, Nicholas Winograd - Show less +3 more 29 Aug 2017-Journal of Physical Chemistry C 6 Citations	Not addressed in the paper.
Open access•Journal Article•DOI Toward understanding weak matrix effects in TOF SIMS Lev D. Gelb, Amy V. Walker - Show less +1 more 20 Mar 2018-Journal of Vacuum Science & Technology. B. Nanotechnology and Microelectronics: Materials, Processing, Measurement, and Phenomena 3 Citations	Not addressed in the paper.
Journal Article•DOI Improvement of biomolecular analysis in thin films using in situ matrix enhanced secondary ion mass spectrometry. Konstantin Moshkunov, Benjamin Tomasetti, Thomas Daphnis, Vincent Delmez, Kevin Vanvarenberg, Véronique Préat, Matthias Lorenz, Matthias Lorenz, Jusal Quanico, Geert Baggerman, Geert Baggerman, Filip Lemière, Christine Dupont, Arnaud Delcorte - Show less +13 more 25 Oct 2021-Analyst 3 Citations	Not addressed in the paper.
Journal Article•DOI Investigating matrix effects of different combinations of lipids and peptides on TOF-SIMS data. Keisuke Mizomichi, Takayuki Yamagishi, Tomoko Kawashima, Michael Dürr, Satoka Aoyagi - Show less +4 more 02 Apr 2020-Biointerphases 1 Citations	Not addressed in the paper.

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