Is MEK involved in antimicrobial peptide production?
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MEK, a homologue gene in Chinese mitten crab Eriocheir sinensis (EsMEK), plays an important role in regulating the expression of antimicrobial peptides (AMPs) through the MEK-ERK pathway . The mRNA levels of EsMEK increased significantly in hemocytes when challenged with lipopolysaccharide (LPS) and Aeromonas hydrophila . Inhibition of EsMEK by specific dsRNA resulted in a significant decrease in the mRNA expression levels of AMPs, including EsWAP, EsDWD1, and EsALF, in LPS-challenged crabs . Downstream pathway analysis revealed a prominent decrease in the phosphorylation of EsERK after EsMEK inhibition . Therefore, MEK is indeed involved in antimicrobial peptide production .
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13 Citations | The provided paper does not mention anything about MEK involvement in antimicrobial peptide production. |
| The paper states that the MEK homologue gene in Chinese mitten crab Eriocheir sinensis (EsMEK) plays an important role in regulating the expression of antimicrobial peptides through the MEK-ERK pathway. Therefore, MEK is involved in antimicrobial peptide production. | |
| The provided paper does not mention anything about MEK or its involvement in antimicrobial peptide production. | |
30 Apr 2015 2 Citations | The provided paper does not mention anything about MEK involvement in antimicrobial peptide production. |
| The provided paper does not mention anything about MEK or its involvement in antimicrobial peptide production. |
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