Q
Qingsong Xu
Researcher at Dalian Ocean University
Publications - 31
Citations - 1169
Qingsong Xu is an academic researcher from Dalian Ocean University. The author has contributed to research in topics: MAPK/ERK pathway & Mitogen-activated protein kinase. The author has an hindex of 19, co-authored 29 publications receiving 945 citations. Previous affiliations of Qingsong Xu include University of Oklahoma Health Sciences Center & Dalian Institute of Chemical Physics.
Papers
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Journal ArticleDOI
Potential roles of N-glycosylation in cell adhesion
Jianguo Gu,Tomoya Isaji,Qingsong Xu,Qingsong Xu,Yoshinobu Kariya,Yoshinobu Kariya,Wei Gu,Tomohiko Fukuda,Yuguang Du +8 more
TL;DR: Here, this work focuses mainly on the modification of N-glycans of integrins and laminin-332, and a mutual regulation between cell adhesion and bisected N- glycan expression, to address the important roles ofN- glycans in cellAdhesion.
Journal ArticleDOI
Roles of N-acetylglucosaminyltransferase III in epithelial-to-mesenchymal transition induced by transforming growth factor β1 (TGF-β1) in epithelial cell lines.
Qingsong Xu,Tomoya Isaji,Yingying Lu,Wei Gu,Madoka Kondo,Tomohiko Fukuda,Yuguang Du,Jianguo Gu +7 more
TL;DR: It is shown how transforming growth factor β1 down-regulates expression of N-acetylglucosaminyltransferase III (GnT-III) during EMT-like changes, which is the first to clearly demonstrate that GnT- III affects cell properties, which in turn influence EMT -like changes.
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Chitosan oligosaccharides inhibit LPS-induced over-expression of IL-6 and TNF-α in RAW264.7 macrophage cells through blockade of mitogen-activated protein kinase (MAPK) and PI3K/Akt signaling pathways
TL;DR: Investigation suggests chitosan oligomers inhibited the elevated expression of IL-6/TNF-α in LPS-induced macrophages, regulated by MAPKs and PI3K/Akt pathways dependent on NF-κB/AP-1 activation.
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Characterization of a new endo-type alginate lyase from Vibrio sp. W13.
TL;DR: The TLC and ESI-MS analysis suggested that Algb mainly released oligosaccharides with DP of 2-5 from the four kinds of substrates in an endolytic manner, suggesting that it may be a potent tool to produce alginate oligosACcharideswith low DP.
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Chitosan oligosaccharides block LPS-induced O-GlcNAcylation of NF-κB and endothelial inflammatory response.
TL;DR: COS decreased OGT-dependent O-GlcNAcylation of NF-κB and thereby attenuated LPS-induced vascular endothelial inflammatory response, providing evidence both in cultured endothelial cells and mouse model supporting a new mechanism.