Gesine Cornelissen

TL;DR: The panel was to provide an update on the present status of the subject and to identify critical needs and issues for the furthering of the successful development of soft sensor methods in bioprocess engineering research and for industrial applications, in particular with focus on biopharmaceutical applications.

TL;DR: A fully automated production of artificial malaria vaccines was achieved using an integrated bioprocess configured for repeated fed batch cultivations and supplemented with an at‐line monitoring of the target protein production via HPLC.

TL;DR: This paper includes a description of the development of a fully automated production plant, starting with a two step upstream followed by a four step downstream line, including cell clarification, broth cleaning with microfiltration, product concentration with ultrafiltration and purification with column chromatography.

TL;DR: Experiments for determination of reaction kinetics, optimization of productivity in high‐cell density cultures and Integrated Bioprocessing are outlined, along with detailed illustration of the realization of the methods at industrial pilot plant scale.

TL;DR: The overall aim of the interdisciplinary research project "PharmCycle" is to reduce the contamination of the aquatic environment with antibiotics by developing sustainable antibiotics, improving the environmental risk assessment of antibiotics, and reducing the discharges of antibiotics in the wastewater outlet.