Is spinal alignment genetically predefined?
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Spinal alignment is influenced by genetic factors, as demonstrated in research on adolescent idiopathic scoliosis (AIS). Genetic regulation of structural components of the axial skeleton, intervertebral discs, and connective tissues plays a crucial role in maintaining spinal alignment. Studies have identified genes like ADGRG6 that are essential for spine morphology and biomechanical properties of tissues, highlighting the genetic basis of spinal alignment. Additionally, advancements in technology, such as utilizing neural networks, have enabled precise clinical assessment of spinal malalignment based on genetic predispositions and anatomical landmarks. Overall, genetic variations and mutations can predispose individuals to spinal conditions, emphasizing the genetic predefinition of spinal alignment.
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| Papers (5) | Insight |
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| Genetic variations play a role in spinal conditions, suggesting a genetic predisposition, but the complexity indicates that spinal alignment is not solely genetically predefined. | |
| Genetic regulation of G protein-coupled receptor Adgrg6 in cartilaginous and dense connective tissues is crucial for maintaining spine alignment, indicating a genetic component in spinal alignment. | |
8 Citations | Genetic regulation of ADGRG6 in cartilaginous and dense connective tissues is essential for maintaining spine alignment, indicating a genetic component in spinal alignment maintenance. |
Related Questions
How spinal alignment affect qol in elderly?9 answersSpinal alignment significantly affects the quality of life (QoL) in the elderly, with various studies highlighting its impact on both physical and mental health dimensions. Research indicates that neuropathic pain (NeP) and spinal inclination are critical factors that negatively influence physical and mental QoL in middle-aged and elderly populations. Specifically, subjects with NeP and positive spinal inclination exhibit more severe pain, lower gait speed, and higher rates of osteoporosis, which are associated with lower QoL scores. Lumbar kyphosis, rather than thoracic kyphosis, has been identified as a more influential factor on QoL, with physical performance, including back muscle strength and spinal range of motion, being closely linked to back-pain-specific QoL.
The association between sagittal malalignment and locomotive syndrome, sarcopenia, and physical function further elucidates the impact of spinal alignment on QoL. A significant correlation exists between spinal inclination angle and both low back pain-related QoL and physical performance measures, such as the timed up-and-go test. Moreover, lower limb compensation for spinal sagittal malalignment, including knee flexion, has been shown to negatively affect physical QoL scores, highlighting the interconnectedness of spinal alignment and lower limb function.
Operative care for spinal deformity in the elderly, aimed at improving spinal alignment, has been shown to significantly enhance health-related QoL, underscoring the importance of addressing spinal malalignment. Vertebral fractures and spinal malalignment have been linked to greater disability and impaired spinopelvic alignment, further emphasizing the relationship between spinal health and QoL. Postmenopausal osteoporosis, characterized by increased spinal kyphosis and muscle weakness, also results in lower QoL, indicating the role of spinal alignment and muscular strength in maintaining QoL.
The Scoliosis Research Society-Schwab classification's sagittal modifiers, such as pelvic tilt and lumbar lordosis, have dose-response relationships with back pain-specific QoL, suggesting that spinal alignment directly influences QoL. Surgical interventions that address spinal deformity and improve sagittal balance have been shown to yield better outcomes in terms of global spinal alignments and QoL, albeit with a higher risk of complications. Finally, exercise targeting muscle strength and spinal range of motion can positively influence QoL by impacting primary factors related to spinal alignment.
Do adult twins have the same spinal alignment?5 answersAdult twins may exhibit similarities in spinal alignment due to potential genetic factors. Studies have highlighted cases of identical twins simultaneously experiencing severe lumbar disc herniation, suggesting a possible hereditary influence on spinal degeneration. Research on spino-pelvic alignment in adults has shown correlations between age and various parameters like thoracic kyphosis, lumbar lordosis, pelvic tilt, and pelvic incidence, indicating age-related changes in spinal alignment. Evaluating spinal deformities requires comprehensive radiographic analysis, emphasizing the importance of assessing spinopelvic parameters for surgical correction. Therefore, while adult twins may not have identical spinal alignment, genetic predispositions and age-related changes can contribute to similarities in their spino-pelvic parameters.
What is the role of visualization in confirming spine alignment during exercise?5 answersVisualization plays a crucial role in confirming spine alignment during exercise. It allows users to visually assess the accuracy of their alignment and make necessary adjustments. For example, Ahmet et al. developed a visualization system that indicates regions of insufficient accuracy in the alignment of an instrument, guiding the user's attention to areas that need improvement. Similarly, Weisberg and Sapan created a device that provides continuous visual indications of spinal posture, helping computer users maintain a preferred posture while seated. In the context of scoliosis diagnosis and monitoring, Church et al. used ultrasound imaging and a 3D transform field to visualize the deformation of the patient's spine, providing an intuitive representation of the scoliotic spine. These visualizations aid users in assessing and adjusting their spine alignment during exercise, promoting proper form and reducing the risk of injury.
How does spinal alignment affect spinal loading?4 answersSpinal alignment has a significant impact on spinal loading. Changes in global sagittal alignment, lumbar typology, and sacral inclination affect intervertebral loads in the lumbar spine and spinal muscle activation. Different patterns of sagittal balance, such as variations in lumbar lordosis, sacral slope, and C7 plumb line, also influence the loads acting in the lumbar spine. An increase in thoracic kyphosis, without postural adjustment, leads to higher compressive loading in the thoracolumbar and lumbar regions. Following physiotherapist's instructions and supporting the upper body by the arms can minimize the high forces acting on the spine when changing body positions. Additionally, the bent forward posture increases stresses and compression forces in intervertebral discs, highlighting the importance of lifting light objects and maintaining an erect posture to minimize spine load.
Is scoliosis a heredity or genetic?5 answersScoliosis is believed to have a genetic component and is considered to be a complex disease with a polygenic background. Multiple studies have shown evidence of genetic factors playing a role in the development of scoliosis. The etiology of scoliosis in osteogenesis imperfecta (OI), a heritable connective tissue disorder, has been linked to collagen-related gene mutations. The genetic inheritance patterns proposed for scoliosis include autosomal dominant, X-linked, multigene, or multifactorial. However, the exact mode of inheritance has not been definitively proven, and it is likely that scoliosis has a multifactorial mode of inheritance with variable penetrance. Overall, scoliosis is considered to have a genetic basis, but the specific genetic mechanisms and inheritance patterns are still being studied.
Is scoliosis is genetic/heredity?3 answersScoliosis is believed to have a genetic component and is considered to be a complex disease with a polygenic background. The etiology of scoliosis is still not fully understood, but it is thought to involve a combination of genetic risk variants, ranging from rare to common. The proposed modes of inheritance for scoliosis include autosomal dominant, X-linked, multigene, or multifactorial patterns. However, none of these modes of inheritance have been definitively proven, and it is likely that a multifactorial mode of inheritance with variable penetrance is the most likely method. Animal models have been used to study the pathogenesis of scoliosis and have provided insights into the genetic factors involved. Overall, the evidence suggests that scoliosis has a genetic/hereditary component, but further research is needed to fully understand the underlying mechanisms.