Is there an ion complex with temozolomide? What is the best synthetic route to obtain these compounds?
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Yes, there is an ion complex with temozolomide. The reaction of CdCl2·2H2O with temozolomide forms the complex [Cd(TMZ)Cl2]n, as characterized by various analytical techniques . The best synthetic route to obtain temozolomide involves several steps. One method includes formylating N-methylurea, cyclizing the formylated product with 2-amino-2-ethyl cyanoacetate, and further reactions to yield temozolomide with high yield and purity . Another method involves synthesizing temozolomide by reacting 5-amino-imidazole-4-formamide with specific reagents under controlled conditions, resulting in a high-quality product suitable for large-scale production . Additionally, a modified synthetic method introduces a new oxidation ring-closing reagent to improve reaction yield and control, avoiding the use of toxic compounds like methyl isocyanate .
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| Papers (4) | Insight |
|---|---|
| Not addressed in the paper. The synthetic method for temozolomide involves a new oxidation ring-closing reagent, enhancing yield, controllability, and avoiding toxic methyl isocyanate, as per the research. | |
| Not addressed in the paper. The best synthetic route for temozolomide involves sequential reactions starting with 5-amino-imidazole-4-formamide and methyl isocyanate in various solvents for high purity and yield. | |
| Yes, a cadmium complex of temozolomide ([Cd(TMZ)Cl2]n) was synthesized. The best synthetic route involves reacting CdCl2·2H2O with temozolomide, as detailed in the paper. | |
| Not addressed in the paper. |
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