Is trim26 an oncogene?
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TRIM26 is regarded as an oncogene in non-small cell lung cancer (NSCLC) . It is downregulated in NSCLC tissues and inhibits NSCLC cell proliferation and migration. TRIM26 acts as a ubiquitin ligase for PBX1, leading to its degradation and inhibition of PBX1 transcriptional activity . Overexpression of TRIM26 promotes NSCLC proliferation, colony formation, and migration . In colorectal cancer (CRC), TRIM26 is upregulated and associated with tumor invasion, metastasis, and poor prognosis . TRIM26 promotes CRC cell proliferation, invasion, and metastasis, and activates the AKT pathway and epithelial-mesenchymal transition . In endometrial carcinoma, TRIM26 is downregulated and its overexpression suppresses tumor growth by regulating the AKT pathway and apoptosis . In vaginal epithelial cells, TRIM26 is upregulated by HSV-2 infection and enhances viral replication by inhibiting interferon production and ISG activation . In renal cell carcinoma (RCC), TRIM27, a member of the TRIM family, is elevated and promotes cell proliferation while inhibiting apoptosis through NF-κB signaling . Therefore, TRIM26 and TRIM27 have oncogenic roles in NSCLC, CRC, endometrial carcinoma, and RCC.
Answers from top 5 papers
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| Papers (5) | Insight |
|---|---|
| The paper does not mention anything about TRIM26 being an oncogene. The paper focuses on the role of TRIM27 in renal cell carcinoma (RCC). | |
3 Citations | The provided paper does not mention whether TRIM26 is an oncogene or not. The paper focuses on the role of TRIM26 in facilitating HSV-2 infection and downregulating antiviral responses. |
| The paper does not explicitly state whether TRIM26 is an oncogene or not. The paper focuses on the positive correlation between TRIM26 expression and overall survival in gynecological tumors, including endometrial carcinoma. It also discusses the role of TRIM26 in regulating the AKT pathway and apoptosis process to inhibit the growth of endometrial carcinoma. | |
| The provided paper does not mention anything about TRIM26. | |
| The paper does not explicitly state whether TRIM26 is an oncogene or not. |
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