Is trimetazidine blood doping?
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57 Citations | Trimetazidine exerts its anti-ischemic action by modulating cardiac metabolism without altering the hemodynamic functions, therefore represents an excellent complementary potential to the conventional angina treatment. |
34 Citations | Trimetazidine administered a few days before PTCA appears to be a cardioprotective agent for the prevention of myocardial ischaemia. |
38 Citations | These results suggest that trimetazidine protects against dephosphorylation of nucleotides and ischemic damage. |
19 Citations | Such a protective effect may participate in the antiaggregatory properties of trimetazidine. |
25 Citations | The present data suggest that trimetazidine may be an effective adjunct therapy for these patients, but further investigation is needed to confirm these findings. |
19 Citations | The membrane effects reported here could participate in the protection of cell metabolism afforded by a long-term treatment with trimetazidine. |
41 Citations | The present observations indicate the need of further research to explore the effect of trimetazidine during longer treatment period or with more selected patient population. |
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What is trimetazidine used for?5 answersTrimetazidine is utilized for various purposes based on research findings. It has been studied for its efficacy in improving clinical outcomes in patients with chronic heart failure (CHF) and comorbid cardiopulmonary conditions like ischemic heart disease (IHD) and chronic obstructive pulmonary disease (COPD). Additionally, trimetazidine has shown potential as a modifier of lipid profiles, exhibiting a hypolipidemic effect when used alongside doxorubicin-cyclophosphamide chemotherapy. However, its use in patients with ischemic heart disease and epilepsy may not be beneficial due to interactions with antiepileptic drugs, affecting their efficacy and motor coordination. Furthermore, trimetazidine has demonstrated positive effects in normal, hyperlipidemic, and diabetic rats, showing potential against syndromes induced by streptozotocin. Lastly, trimetazidine has been analyzed in sports drug testing through dried blood spot analysis, particularly in differentiating its use from lomerizine and confirming its presence in the body.
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