C
Catherine Astarie-Dequeker
Researcher at Paul Sabatier University
Publications - 27
Citations - 2866
Catherine Astarie-Dequeker is an academic researcher from Paul Sabatier University. The author has contributed to research in topics: Phagosome & Phagocytosis. The author has an hindex of 18, co-authored 26 publications receiving 2650 citations. Previous affiliations of Catherine Astarie-Dequeker include Centre national de la recherche scientifique & University of Toulouse.
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Journal ArticleDOI
Nuclear gene OPA1, encoding a mitochondrial dynamin-related protein, is mutated in dominant optic atrophy.
Cécile Delettre,Guy Lenaers,Jean-Michel Griffoin,Nadine Gigarel,Corinne Lorenzo,Pascale Belenguer,Laetitia Pelloquin,J. Grosgeorge,Claude Turc-Carel,Eric Perret,Catherine Astarie-Dequeker,Laetitia Lasquellec,B. Arnaud,Bernard Ducommun,Josseline Kaplan,Christian P. Hamel +15 more
TL;DR: A nuclear gene, OPA1, is described here a nuclear gene that maps within the candidate region and encodes a dynamin-related protein localized to mitochondria, demonstrating a role for mitochondria in retinal ganglion cell pathophysiology.
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The Mannose Receptor Mediates Uptake of Pathogenic and Nonpathogenic Mycobacteria and Bypasses Bactericidal Responses in Human Macrophages
Catherine Astarie-Dequeker,Elsa-Noah N’Diaye,V. Le Cabec,Michael Rittig,J. Prandi,Isabelle Maridonneau-Parini +5 more
TL;DR: It is demonstrated that MR-dependent phagocytosis is coupled neither to the activation of NADPH oxidase nor to the maturation of phagosomes until fusion with the Hck compartment and therefore constitutes a safe portal of entry for microorganisms.
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Phthiocerol dimycocerosates of M. tuberculosis participate in macrophage invasion by inducing changes in the organization of plasma membrane lipids.
Catherine Astarie-Dequeker,Laurent Le Guyader,Wladimir Malaga,Fam-Ky Seaphanh,Christian Chalut,André Lopez,Christophe Guilhot +6 more
TL;DR: DIM is proposed to control the invasion of macrophages by Mtb by targeting lipid organisation in the host membrane, thereby modifying its biophysical properties and contributing to the control of phagosomal pH driving bacilli in a protective niche.
Journal ArticleDOI
Evolutionary history of tuberculosis shaped by conserved mutations in the PhoPR virulence regulator
Jesús Gonzalo-Asensio,Wladimir Malaga,Alexandre Pawlik,Catherine Astarie-Dequeker,Catherine Astarie-Dequeker,Charlotte Passemar,Charlotte Passemar,Flavie Moreau,Flavie Moreau,Françoise Laval,Françoise Laval,Mamadou Daffé,Mamadou Daffé,Carlos Martin,Roland Brosch,Christophe Guilhot,Christophe Guilhot +16 more
TL;DR: It is shown by genetic transfer and virulence experiments that specific mutations in a virulence regulator contribute to lower fitness and virosity of M. bovis and related strains for the human host, likely obstructing the capacity of causing overt disease needed for efficient human-to-human transmission.
Journal ArticleDOI
The impact of the absence of glycopeptidolipids on the ultrastructure, cell surface and cell wall properties, and phagocytosis of Mycobacterium smegmatis.
Gilles Etienne,Christelle Villeneuve,Helen Billman-Jacobe,Catherine Astarie-Dequeker,Marie-Ange Dupont,Mamadou Daffé +5 more
TL;DR: Data showed that, in addition to being distinctive markers of numerous mycobacterial species, GPLs play a role in the bacterial phenotype, surface properties and cell wall permeability.